| Correlation between cardiac enzyme elevation and the duration of cardiopulmonary resuscitation. | |
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MedLine Citation:
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PMID: 16416680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular disease is the leading cause of death in the United States. Acute myocardial infarction (MI) is defined as necrosis of myocardial cells. Several studies have shown that cardiac markers are elevated after successful cardiopulmonary resuscitation (CPR) due to physical as well as electrical trauma. Correlation has never been established between an elevation in cardiac markers and patient age, the amount of trauma induced during resuscitation, or the duration of chest compression. Previous studies have determined that cardiac troponin (cTnl) is the most sensitive marker in cardiac injury. In this study, we hypothesized that the duration of CPR and the patient's age had a direct correlation with cardiac injury demonstrated as an elevation of cTnl. We analyzed retrospectively 81 patients that underwent successful CPR in an in-hospital setting. 13 patients were excluded from the analysis due to positive cTnl prior to cardiac arrest. Duration of CPR, as well as cTnl levels before and after cardiac arrest were recorded and analyzed in the remaining 68 patients. Patients with a negative cTnl after successful CPR (n=30) were stratified into Group A. The remaining patients (Group B) had a positive cTnl ranging from 2.2-31 ng/ml. The mean age and the mean duration of CPR in minutes were calculated and compared using t-Test analysis. There was no statistical difference in age between Group A and Group B. Patients in Group A had a mean CPR duration of 12.2 minutes, while patients in Group B had a mean CPR duration of 19.8 minutes (p < 0.02). We found that the duration of cardiopulmonary resuscitation was positively associated with the elevation of cardiac markers. |
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Authors:
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Sotir Polena; Kuan H Shen; Eirene Mamakos; Peter J Chuang; Mohan Sharma; Pasaka Griciene; Aleksandr A Ponomarev; Jonas Gintautas; Rajen Maniar |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the Western Pharmacology Society Volume: 48 ISSN: 0083-8969 ISO Abbreviation: Proc. West. Pharmacol. Soc. Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-18 Completed Date: 2006-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505899 Medline TA: Proc West Pharmacol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 136-8 Citation Subset: IM |
Affiliation:
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Flushing Hospital Medical Center, NY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / metabolism Biological Markers Cardiopulmonary Resuscitation* Female Humans Male Myocardium / enzymology* Retrospective Studies Time Factors Troponin I / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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