Document Detail

Correlation between blood prostaglandins and blood pressure in chronic renal failure.
MedLine Citation:
PMID:  3306429     Owner:  NLM     Status:  MEDLINE    
Plasma prostaglandins (PGs; PGE2, PGF2 alpha, 6-keto-PGF 1 alpha and TXB2) and plasma renin activity (PRA) were measured in 94 end-stage renal disease (ESRD) patients including 15 undialyzed, 74 maintenance-hemodialyzed and 5 anephric patients, and in 27 healthy controls. In the healthy controls, 6-keto-PGF 1 alpha inversely correlated with age, while TXB2 and the TXB2/6-keto-PGF 1 alpha ratio correlated with age. In the ESRD patients, 6-keto-PGF 1 alpha showed a tendency to decrease with age, and the TXB2/6-keto-PGF 1 alpha ratio significantly correlated with age. The undialyzed group showed significantly higher blood pressure and TXB2 but significantly lower 6-keto-PGF1 alpha compared to the other groups. In the dialyzed group, PGE2 and 6-keto-PGF1 alpha tended to be lower and TXB2 higher compared to the healthy control group. In the dialyzed group, 6-keto-PGF1 alpha correlated inversely with blood pressure independently from PRA. As for PGF2 alpha, it was higher in the undialyzed, dialyzed and anephric groups than in the healthy control group. These results suggested that PGs were involved in blood pressure abnormalities, and that PGI2 played an important role in controlling blood pressure in ESRD patients as one of the depressor factors.
T Kishimoto; T Terada; T Okahara; Y Abe; S Yamagami; M Maekawa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  47     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-20     Completed Date:  1987-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
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MeSH Terms
Aging / blood
Blood Pressure*
Kidney Failure, Chronic / blood*,  enzymology,  therapy
Middle Aged
Prostaglandins / blood*
Renal Dialysis
Renin / blood*
Reg. No./Substance:
0/Prostaglandins; EC

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