| Correlation between biochemical tests, parameters of drug elimination and hepatic enzyme induction in chronic liver diseases. | |
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MedLine Citation:
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PMID: 6674914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biochemical liver function tests form an integral part of diagnostic practice in hepatology. In this study the parameters suited for the estimation of drug elimination and of the induced state of the liver, thus the excretion of D-glucaric acid, of menthol glucuronide and the parameters of antipyrine and sulphadimidine kinetics were correlated with the results of biochemical laboratory tests in patients with chronic liver disease. The aim was to establish universally valid quantitative correlations between the above results. Multiple relationships were revealed, but generally valid correlations for the group of liver diseases occurred only in special relationships (serum albumin level and antipyrine T1/2; serum bilirubin level and sulphadimidine T1/2). The results have been evaluated from the methodological aspect to work out an appropriate dosage regime in liver diseases. |
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Authors:
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T Horváth; A Pár; T Beró; I Kádas; C Fábián; T Jávor |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta medica Hungarica Volume: 40 ISSN: 0236-5286 ISO Abbreviation: Acta Med Hung Publication Date: 1983 |
Date Detail:
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Created Date: 1984-05-29 Completed Date: 1984-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8400269 Medline TA: Acta Med Hung Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 203-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipyrine / metabolism Bilirubin / blood Chronic Disease Enzyme Induction Female Glucaric Acid / metabolism Humans Kinetics Liver Diseases / enzymology*, metabolism Liver Function Tests* Male Menthol / metabolism Middle Aged Serum Albumin / metabolism Sulfamethazine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 1490-04-6/Menthol; 25525-21-7/Glucaric Acid; 57-68-1/Sulfamethazine; 60-80-0/Antipyrine; 635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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