| Correlation between behavioral and pathological changes in the evaluation of neurotoxicity. | |
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MedLine Citation:
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PMID: 2603164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently the EPA has implemented new guidelines under Section 4 of TSCA to undertake neurotoxicity testing. It is expected that other agencies, both national and international, will follow suit. The evaluation of neurotoxicity will be based primarily on behavioral and morphological observations and particularly on the correlation between them. Initially, considerable information will have to be gathered from various laboratories to form the background data on which decisions of toxic effects can be made. This paper presents our experience to date with behavioral and neuropathological procedures for the evaluation of chemical compounds or dietary regimens in rats for potential neurotoxicity. Reference is made to acrylamide, 2,5-hexanedione, 3,3'-iminodipropionitrile, amphetamine, physostigmine, ethanol, triethyltin, food and water deprivation, and carbon tetrachloride. The question of whether every change induced by xenobiotics can be considered as a sign of toxicity is discussed. |
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Authors:
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B Broxup; K Robinson; G Losos; P Beyrouty |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology and applied pharmacology Volume: 101 ISSN: 0041-008X ISO Abbreviation: Toxicol. Appl. Pharmacol. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-02-08 Completed Date: 1990-02-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0416575 Medline TA: Toxicol Appl Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 510-20 Citation Subset: IM |
Affiliation:
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Bio-Research Laboratories Ltd., Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamide Acrylamides / toxicity Amphetamine / toxicity Animals Behavior, Animal / drug effects* Dose-Response Relationship, Drug Ethanol / toxicity Food Deprivation Forelimb / drug effects Hindlimb / drug effects Locomotion / drug effects Male Motor Activity / drug effects* Neurotoxins / toxicity* Nitriles / toxicity Peripheral Nerves / drug effects*, pathology Physostigmine / toxicity Rats Rats, Inbred Strains Water Deprivation |
| Chemical | |
Reg. No./Substance:
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0/Acrylamides; 0/Neurotoxins; 0/Nitriles; 111-94-4/3,3'-iminodipropionitrile; 300-62-9/Amphetamine; 57-47-6/Physostigmine; 64-17-5/Ethanol; 79-06-1/Acrylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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