Document Detail

Correlation between behavioral and pathological changes in the evaluation of neurotoxicity.
MedLine Citation:
PMID:  2603164     Owner:  NLM     Status:  MEDLINE    
Recently the EPA has implemented new guidelines under Section 4 of TSCA to undertake neurotoxicity testing. It is expected that other agencies, both national and international, will follow suit. The evaluation of neurotoxicity will be based primarily on behavioral and morphological observations and particularly on the correlation between them. Initially, considerable information will have to be gathered from various laboratories to form the background data on which decisions of toxic effects can be made. This paper presents our experience to date with behavioral and neuropathological procedures for the evaluation of chemical compounds or dietary regimens in rats for potential neurotoxicity. Reference is made to acrylamide, 2,5-hexanedione, 3,3'-iminodipropionitrile, amphetamine, physostigmine, ethanol, triethyltin, food and water deprivation, and carbon tetrachloride. The question of whether every change induced by xenobiotics can be considered as a sign of toxicity is discussed.
B Broxup; K Robinson; G Losos; P Beyrouty
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  101     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-08     Completed Date:  1990-02-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  510-20     Citation Subset:  IM    
Bio-Research Laboratories Ltd., Montreal, Quebec, Canada.
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MeSH Terms
Acrylamides / toxicity
Amphetamine / toxicity
Behavior, Animal / drug effects*
Dose-Response Relationship, Drug
Ethanol / toxicity
Food Deprivation
Forelimb / drug effects
Hindlimb / drug effects
Locomotion / drug effects
Motor Activity / drug effects*
Neurotoxins / toxicity*
Nitriles / toxicity
Peripheral Nerves / drug effects*,  pathology
Physostigmine / toxicity
Rats, Inbred Strains
Water Deprivation
Reg. No./Substance:
0/Acrylamides; 0/Neurotoxins; 0/Nitriles; 111-94-4/3,3'-iminodipropionitrile; 300-62-9/Amphetamine; 57-47-6/Physostigmine; 64-17-5/Ethanol; 79-06-1/Acrylamide

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