Document Detail


Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries.
MedLine Citation:
PMID:  17397315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic infections, such as periodontitis, have been associated with an increased risk for atherosclerosis and coronary artery disease. The aim of this study was to investigate biopsy samples of coronary and internal mammary arteries for the presence of putative pathogenic bacteria (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythensis), Chlamydia pneumoniae, and human cytomegalovirus (CMV). METHODS: Patients with a diagnosis of coronary artery disease were included in the study. Fifteen coronary arteries with atherosclerosis and 15 internal mammary arteries without clinically assessable atherosclerotic degeneration were investigated. Both groups of specimens were obtained during coronary artery bypass grafting surgery. In all cases, the coronary and mammary artery specimens were taken from the same patient. The detection of periodontal pathogens, C. pneumoniae, and CMV was done by polymerase chain reaction analysis. RESULTS: Bacterial DNA was found in nine of 15 (60%) coronary artery biopsy samples: P. gingivalis in eight (53.33%), A. actinomycetemcomitans in four (26.67%), P. intermedia in five (33.33%), and T. forsythensis in two (13.33%) samples; CMV was detected in 10 (66.67%) samples, and C. pneumoniae was detected in five (33.33%) samples. Some of the samples contained more than one type of bacteria. Periodontal pathogens were not detected in internal mammary artery biopsies, whereas CMV was present in seven (46.67%) samples and C. pneumoniae was present in six (40%) samples. CONCLUSION: The absence of putative pathogenic bacteria in internal mammary arteries, which are known to be affected rarely by atherosclerotic changes, and their presence in a high percentage of atherosclerotic coronary arteries support the concept that periodontal organisms are associated with the development and progression of atherosclerosis.
Authors:
Ana Pucar; Jelena Milasin; Vojislav Lekovic; Miroslav Vukadinovic; Miljko Ristic; Svetozar Putnik; E Barrie Kenney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of periodontology     Volume:  78     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  677-82     Citation Subset:  D; IM    
Affiliation:
Department of Periodontology and Oral Medicine, School of Dentistry, University of Belgrade, Belgrade, Serbia. anapucar@sbb.co.yu
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / microbiology*
Chlamydophila pneumoniae / isolation & purification
Coronary Vessels / microbiology*
Cytomegalovirus / isolation & purification
Female
Humans
Male
Mammary Arteries / microbiology*
Middle Aged
Periodontitis / microbiology*
Polymerase Chain Reaction / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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