Document Detail

Correlation between the appearance of gelatinases in the synovial fluid of patients with rheumatoid arthritis and polymorphonuclear elastase, stromelysin-1, and the tissue inhibitor of metalloproteinase-1.
MedLine Citation:
PMID:  9177919     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To clarify whether gelatinases in the synovial fluid are related to rheumatoid arthritis (RA). METHODS: Gelatinases in the synovial fluid of patients with RA were analyzed by gelatin zymography. RESULTS: We classified patients into 3 distinct groups based on the gelatinases present. Although inactive gelatinase A was found in the synovial fluid of all patients with RA, the presence of gelatinase B varied: group I contained none, group II contained inactive gelatinase B, and group III contained active gelatinase B. The presence of gelatinase B was positively correlated with the polymorphonuclear (PMN) elastase content of the synovial fluid. Furthermore, the presence of activated gelatinase B correlated well with the stromelysin-1 content. Conversely, large amounts of the tissue inhibitor of metalloproteinase-1 (TIMP-1) were found in the synovial fluid of patients in group II. CONCLUSION: The appearance and form of gelatinase B may reflect the inflammatory condition of patients with RA.
Y Watanabe; Y Shimamori; N Fujii; R Yamaguchi; Y Fujimoto; H Matsuno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  15     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-07-24     Completed Date:  1997-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
Department of Clinical Biochemistry, Hokkaido Institute of Pharmaceutical Sciences, Japan.
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MeSH Terms
Arthritis, Rheumatoid / metabolism*
Collagenases / metabolism*
Glycoproteins / metabolism*
Leukocyte Elastase / metabolism*
Matrix Metalloproteinase 3 / metabolism*
Matrix Metalloproteinase 9
Protease Inhibitors / metabolism*
Synovial Fluid / metabolism*
Tissue Inhibitor of Metalloproteinases
Reg. No./Substance:
0/Glycoproteins; 0/Protease Inhibitors; 0/Tissue Inhibitor of Metalloproteinases; EC Elastase; EC 3.4.24.-/Collagenases; EC Metalloproteinase 3; EC Metalloproteinase 9

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