| Correlation between the appearance of gelatinases in the synovial fluid of patients with rheumatoid arthritis and polymorphonuclear elastase, stromelysin-1, and the tissue inhibitor of metalloproteinase-1. | |
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MedLine Citation:
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PMID: 9177919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To clarify whether gelatinases in the synovial fluid are related to rheumatoid arthritis (RA). METHODS: Gelatinases in the synovial fluid of patients with RA were analyzed by gelatin zymography. RESULTS: We classified patients into 3 distinct groups based on the gelatinases present. Although inactive gelatinase A was found in the synovial fluid of all patients with RA, the presence of gelatinase B varied: group I contained none, group II contained inactive gelatinase B, and group III contained active gelatinase B. The presence of gelatinase B was positively correlated with the polymorphonuclear (PMN) elastase content of the synovial fluid. Furthermore, the presence of activated gelatinase B correlated well with the stromelysin-1 content. Conversely, large amounts of the tissue inhibitor of metalloproteinase-1 (TIMP-1) were found in the synovial fluid of patients in group II. CONCLUSION: The appearance and form of gelatinase B may reflect the inflammatory condition of patients with RA. |
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Authors:
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Y Watanabe; Y Shimamori; N Fujii; R Yamaguchi; Y Fujimoto; H Matsuno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 15 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 1997 May-Jun |
Date Detail:
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Created Date: 1997-07-24 Completed Date: 1997-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: ITALY |
Other Details:
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Languages: eng Pagination: 255-61 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Hokkaido Institute of Pharmaceutical Sciences, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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metabolism* Collagenases / metabolism* Glycoproteins / metabolism* Humans Leukocyte Elastase / metabolism* Matrix Metalloproteinase 3 / metabolism* Matrix Metalloproteinase 9 Protease Inhibitors / metabolism* Synovial Fluid / metabolism* Tissue Inhibitor of Metalloproteinases |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Protease Inhibitors; 0/Tissue Inhibitor of Metalloproteinases; EC 3.4.21.37/Leukocyte Elastase; EC 3.4.24.-/Collagenases; EC 3.4.24.17/Matrix Metalloproteinase 3; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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