Document Detail


Correlation between angiographic and particle image velocimetry quantifications of flow diverters in an in vitro model of elastase-induced rabbit aneurysms.
MedLine Citation:
PMID:  19154077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rupture of a cerebral aneurysm can result in a hemorrhagic stroke. A flow diverter, which is a porous tubular mesh, can be placed across the neck of a cerebral aneurysm to induce the cessation of flow and initiate the formation of an intra-aneurysmal thrombus. By finding a correlation between particle image velocimetry (PIV) and digital subtraction angiography, a better assessment of how well an aneurysm is excluded from the parent artery can be made in the clinical setting. A model of a rabbit elastase-induced aneurysm was connected to a mock circulation loop. The model was then placed under angiography. Recorded angiograms were analyzed so that a contrast concentration-time curve based on the average grayscale intensity inside the aneurysm could be determined. That curve was then fitted to a mathematical model that quantifies the influence of convection and diffusion on contrast transport. Optimized parameters were correlated with the intraneurysmal mean kinetic energy measured by PIV in the same aneurysm model. A strong correlation was observed between the convection and diffusion time constants and the mean kinetic energy inside the aneurysm. Analyzing the flow of angiographic contrast into and out of the aneurysm after implantation of a flow diverter allows for prediction of the efficacy of the device in excluding the aneurysm. Correlating hydrodynamic measures obtained by angiography to those obtained by detailed techniques such as PIV increases confidence in such predictions.
Authors:
Asher L Trager; Chander Sadasivan; Jaehoon Seong; Baruch B Lieber
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  131     ISSN:  0148-0731     ISO Abbreviation:  J Biomech Eng     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-05-13     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  034506     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessel Prosthesis*
Cerebral Angiography / methods*
Contrast Media / diagnostic use
Convection
Diffusion
Hemodynamics
Implants, Experimental
Intracranial Aneurysm / blood*,  radiography*
Kinetics
Models, Theoretical
Pancreatic Elastase / metabolism*
Rabbits
Stents
Grant Support
ID/Acronym/Agency:
NS045753-01A1/NS/NINDS NIH HHS; R01 NS045753/NS/NINDS NIH HHS; R01 NS045753-01A1/NS/NINDS NIH HHS; R01 NS045753-02/NS/NINDS NIH HHS; R01 NS045753-03/NS/NINDS NIH HHS; R01 NS045753-04/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; EC 3.4.21.36/Pancreatic Elastase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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