Document Detail

Correlation between alveolar recruitment/derecruitment and inflection points on the pressure-volume curve.
MedLine Citation:
PMID:  17525844     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether individual alveolar recruitment/derecruitment (R/D) is correlated with the lower and upper inflections points on the inflation and deflation limb of the whole-lung pressure-volume (P-V) curve. DESIGN AND SETTING: Prospective experimental study in an animal research laboratory. SUBJECTS: Five anesthetized rats subjected to saline-lavage lung injury. INTERVENTIONS: Subpleural alveoli were filmed continuously using an in vivo microscope during the generation of a whole-lung P-V curve using the super syringe technique. Alveolar R/D was correlated to the calculated inflection points on both limbs of the P-V curve. MEASUREMENTS AND RESULTS: There was continual alveolar recruitment along the entire inflation limb in all animals. There was some correlation (R2=0.898) between the pressure below which microscopic derecruitment was observed and the upper inflection point on the deflation limb. No correlation was observed between this pressure and the lower inflection point on the inflation limb. CONCLUSIONS: In this physiological experiment in lungs with pure surfactant deactivation we found that individual alveolar recruitment measured by direct visualization was not correlated with the lower inflection point on inflation whereas alveolar derecruitment was correlated with alveolar derecruitment on deflation. These data suggest that inflection points on the P-V curve do not always represent a change in alveolar number.
Joseph D DiRocco; David E Carney; Gary F Nieman
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Publication Detail:
Type:  Journal Article     Date:  2007-05-25
Journal Detail:
Title:  Intensive care medicine     Volume:  33     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-05     Completed Date:  2008-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1204-11     Citation Subset:  IM    
Department of Surgery, Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA.
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MeSH Terms
Lung Compliance / physiology*
Lung Volume Measurements
Pulmonary Alveoli / cytology,  physiology*
Rats, Sprague-Dawley
Comment In:
Intensive Care Med. 2007 Jul;33(7):1114-6   [PMID:  17530218 ]

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