Document Detail

Correlation between acquired pseudo-Pelger-Huet anomaly and involvement of chromosome 17 in chronic myeloid leukemia.
MedLine Citation:
PMID:  3470117     Owner:  NLM     Status:  MEDLINE    
Acquired pseudo-Pelger-Huet neutrophils appeared in the peripheral blood of 11 of 83 Philadelphia-positive chronic myeloid leukemia patients during the blastic phase of the disease. Chromosomal analysis performed at the time of pseudo-Pelger appearance showed karyotype evolution with involvement of the short arms of a chromosome #17. In eight cases an i(17q) was present, in two cases an unbalanced translocation, and in one case monosomy. All these rearrangements had in common the loss of the distal end of the short arm. The morphologic and chromosomal study of the remaining 72 chronic myeloid leukemia patients demonstrated neither pseudo-Pelger nor 17p involvement.
M Sessarego; F Ajmar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  25     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-04-27     Completed Date:  1987-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  IM    
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MeSH Terms
Chromosome Aberrations*
Chromosomes, Human, Pair 17*
Leukemia, Myeloid / etiology,  genetics*
Neutrophils / pathology
Pelger-Huet Anomaly / complications,  genetics*
Preleukemia / genetics

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