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The Correlation between Ventricular Repolarization and Clinical Severity of Spinal Cord Injuries.
MedLine Citation:
PMID:  21277998     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Alteration in ventricular repolarization has been reported in patients with spinal cord injuries (SCIs). However, its clinical impact remains unclear. OBJECTIVES: The study investigated the correlation between SCIs and ventricular repolarization, and the associated clinical impact. METHODS: One hundred and forty-four patients with an SCI were retrospectively reviewed, and were divided into two groups (SCI level ≤ T6, n = 110; SCI level > T6, n = 34). The electrocardiograms were reviewed during acute phase (at emergency room) and chronic phase (more than one year). RESULTS: There were no differences in the underlying diseases, or in ASIA score between the two groups, except there were more patients with tetraplegia among those with an SCI level ≤ T6. For the electrophysiological parameters from the ECGs, the patients with an SCI level ≤ T6 had longer QTc and PR interval than those with an SCI level > T6 during acute phase. In the chronic phase, there were no differences in the electrophysiological parameters between the two groups. Only in patients with an SCI level ≤ T6, a Kaplan-Meier analysis showed that QTc prolongation could predict 30-day mortality after the acute injury. After multivariate Cox regression analysis, only tetraplegia and QTc prolongation were independent predictors of 30-day mortality (odds ratios: 7.85 and 34.62, respectively). In patients with an SCI level ≤ T6, the QTc intervals were shorter in the chronic phase than those during the acute phase. CONCLUSION: QTc interval was associated with the level of acute SCI and predicted the 30-day mortality.
Authors:
Fa-Po Chung; Yu-Feng Hu; Tze-Fan Chao; Satoshi Higa; Henrich Cheng; Yenn-Jiang Lin; Shih-Lin Chang; Li-Wei Lo; Ta-Chuan Tuan; Ching-Tai Tai; Cheng-Hong Li; Yung-Kuo Lin; Shih-Ann Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-25
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  -     ISSN:  1556-3871     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital.
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