Document Detail

Correlation between Doppler Velocities and Duplex Ultrasound Carotid Cross-sectional Percent Stenosis.
MedLine Citation:
PMID:  21889897     Owner:  NLM     Status:  Publisher    
RATIONALE AND OBJECTIVES: Cross-sectional imaging is being increasingly proposed as a suitable tool to characterize carotid plaques. The aim of this work was to correlate the Doppler velocity parameters with the cross-sectional percent stenosis (CPoS) of internal carotid artery (ICA) and to identify the cutoff values of these parameters in five progressive classes of stenosis area severity (ie, 40%-49%, 50%-59%, 60%-69%, 70%-79%, 80%-90%). MATERIALS AND METHODS: High-quality scans from 90 patients (mean age, 74 ± 9 years) with 43%-90% ICA stenosis were analyzed. ICA peak-systolic (PSV) and end-diastolic (EDV) velocities were measured at maximum stenosis level. Total ICA area and residual lumen (RL) were measured to derive the CPoS. A simple physical model described by the equation Velocity = Flow rate/Area was considered. Effectively, the CPoS is expected to negatively correlate with the inverse of velocity parameters, assuming flow rate to be constant. Multiple stepwise regression analyses were used to investigate the relationships between velocity and echographic measures. RESULTS: With CPoS as the dependent variable, the first significant regressor was the inverse ICA-EDV (r(2) = 0.64; P < .0001) followed by inverse ICA-PSV (r(2) = 0.43; P < .0001). ICA-EDV mean values throughout five progressive classes of stenosis were: 28 cm/second for 40%-49% stenosis, 35 cm/second for 50%-59%, 43 cm/second for 60%-69%, 69 cm/second for 70%-79%. and 103 cm/second for 80%-90%. ICA-PSV mean values were: 97 cm/second for 40%-49%, 110 cm/second for 50%-59%, 136 cm/second for 60%-69%, 224 cm/second for 70%-79%, and 286 cm/second for 80%-90%. CONCLUSION: ICA-EDV is the parameter that better correlates with CPoS. Nevertheless, ICA-PSV maintained a highly significant correlation with CPoS. Moreover, the categorization of Doppler parameters in five progressive classes of severity of stenosis could provide physicians with an easily accessible tool in clinical practice, complementary to the morphological evaluation of cross-sectional stenosis.
Guido Rodriguez; Dario Arnaldi; Claudio Campus; Debora Mazzei; Michela Ferrara; Agnese Picco; Francesco Famà; Barbara M Colombo; Flavio Nobili
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-1
Journal Detail:
Title:  Academic radiology     Volume:  -     ISSN:  1878-4046     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 AUR. Published by Elsevier Inc. All rights reserved.
Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Via De Toni, 5, 16132 Genoa, Italy.
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