| The Correlation between the Clinical Laboratory Data and the Telomere Length in Peripheral Blood Leukocytes of Japanese Female Patients with Hypertension. | |
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MedLine Citation:
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PMID: 21369674 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: This study investigated the correlation between the chronological age, telomere length in peripheral blood leukocytes and blood laboratory data of female patients with mild hypertension to identify laboratory data that reflect the biological aging of individuals. Design: Cross-sectional population-based study. Setting: Outpatient clinic of the Department of Cardiovascular, Respiratory, and Geriatric Medicine Kyushu University Hospital at Beppu in Japan. Participants: Outpatients with mild hypertension treated with a low dose of amlodipine. Measurements: The laboratory data of female patients were collected and the telomere length parameters in their peripheral blood leukocytes were determined by Southern blotting. Any correlations between the laboratory data and the telomere length parameters were assessed. Results: The patients showed a positive correlation between the telomere length and the high density lipoprotein, albumin, creatinine, hemoglobin levels, red blood cell counts, and a negative correlation with the globulin level. The extent of subtelomeric methylation of long telomeres tended to correlate negatively with the telomeric attrition. Only the creatinine level correlated with subtelomeric methylation, but not with telomeric length. Conclusion: HDL and the albumin/globulin ratio were potential indicators for individual somatic genomic aging. Creatinine may therefore be a useful indicator for a predisposition for telomeric attrition. |
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Authors:
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T Maeda; J I Oyama; M Sasaki; T Arima; N Makino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of nutrition, health & aging Volume: 15 ISSN: 1760-4788 ISO Abbreviation: J Nutr Health Aging Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100893366 Medline TA: J Nutr Health Aging Country: France |
Other Details:
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Languages: eng Pagination: 240-4 Citation Subset: IM |
Affiliation:
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T. Maeda, The Division of Molecular and Clinical Gerontology, the Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, 874-0838, Japan; e-mail:maedat@beppu.kyushu-u.ac.jp. |
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