| The correlation between CVR-R and carotid atherosclerosis in type 2 diabetes mellitus patients with diabetic neuropathy. | |
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MedLine Citation:
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PMID: 20686328 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We examined the relationship between the coefficient of variation in the R-R intervals (CVR-R) using electrocardiograms and the ultrasonic intima-media thickness (IMT) of the carotid artery, an atherosclerotic parameter, in type 2 diabetes mellitus (DM) patients with diabetic neuropathy (n=47, males/females: 29/18; mean age: 62 years). In this study, the CVR-R-related indexes, including CVR-R at rest (CVR-R(rest)), CVR-R with deep breaths (CVR-R(breath)) and their difference (CVR-R(breath) minus CVR-R(rest): CVR-R(dif)), were defined. Data such as body mass index, smoking habits, hemoglobin A1c, blood pressure, and serum low-density lipoprotein were collected. A significant inverse correlation was observed between max-IMT and CVR-R(dif) (beta=-0.34, p=0.042), but not CVR-R(rest) or CVR-R(breath), in multivariate analyses adjusted for all the data. Therefore, the CVR-R(dif) may serve as a clinical index for the diabetic autonomic neuropathy-atherosclerosis relation in type 2 DM patients. |
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Authors:
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Michiaki Miyamoto; Kazuhiko Kotani; Hiroaki Yagyu; Harumi Koibuchi; Yasutomo Fujii; Kei Konno; Toshiyuki Yamada; Shun Ishibashi; Nobuyuki Taniguchi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of physiological anthropology Volume: 29 ISSN: 1880-6805 ISO Abbreviation: J Physiol Anthropol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269653 Medline TA: J Physiol Anthropol Country: Japan |
Other Details:
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Languages: eng Pagination: 149-52 Citation Subset: IM |
Affiliation:
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Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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