| Correlation between BNP levels and Doppler echocardiographic parameters of left ventricle filling pressure in patients with Chagasic cardiomyopathy. | |
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MedLine Citation:
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PMID: 19452608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiomyopathy is the most important manifestation of Chagas' disease. Brain natriuretic peptide (BNP) level and Doppler echocardiographic parameters for diastolic dysfunction have shown correlation with left ventricle (LV) filling pressures. OBJECTIVES: The purpose of this study is to compare BNP levels with Doppler echocardiographic parameters in patients with chagasic cardiomyopathy. METHODS: Forty-three patients (69.8% men; mean age 41.0 +/- 10.4 years) were submitted to an echocardiographic study and 39 had their BNP levels measured. RESULTS: BNP levels increased with the deterioration of the diastolic function (P=0.025). Pulmonary venous flow parameters were correlated with BNP levels, but E/E'ratio (E'measured at the inferior mitral annulus) was the only diastolic parameter that remained an independent predictor of elevated BNP levels in the multivariate analysis. The area under the receiver-operating curve for BNP to detect E/E' >15 was 0.875. A BNP value of 280.4 pg/ml had a sensitivity of 96% and a specificity of 75% for predicting E/E' >15. CONCLUSIONS: In a group of patients with chagasic cardiomyopathy, BNP levels correlated with diastolic function patterns regardless of systolic function. The E/E'ratio (inferior wall) was the only isolated parameter of diastolic function that was independently associated with BNP levels. |
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Authors:
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Bráulio M R Oliveira; Fernando A Botoni; Antonio L P Ribeiro; Airandes S Pinto; Adelina M Reis; Maria do Carmo P Nunes; Manoel O C Rocha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 26 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-18 Completed Date: 2009-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 521-7 Citation Subset: IM |
Affiliation:
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Postgraduate Course of Tropical Medicine, University Hospital, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. muzzi.bhz@terra.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chagas Cardiomyopathy / blood*, complications, ultrasonography* Echocardiography, Doppler* Female Humans Male Natriuretic Peptide, Brain / blood* Reproducibility of Results Sensitivity and Specificity Ventricular Dysfunction, Left / blood*, etiology, ultrasonography* Ventricular Pressure |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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