Document Detail


Correlation between Apgar score and urinary uric acid to creatinine ratio in perinatal asphyxia.
MedLine Citation:
PMID:  23105787     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was found that the ratios were significantly higher in cases than controls (3.1± 1.3 vs 0.96± 0.54; P < 0.001) and among asphyxia patients, a significant negative linear correlation was found between the uric acid to creatinine ratio and the Apgar score (r = -0.857, P < 0.001). So urinary uric acid to creatinine ratio can be used as an additional non-invasive dispace, easy and at the same time early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and severity grading of asphyxia by Apgar score.
Authors:
Pallab Basu; Sabyasachi Som; Nabendu Choudhuri; Harendranath Das
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Publication Detail:
Type:  Journal Article     Date:  2008-12-20
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  23     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  361-4     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Burdwan Medical College and Hospital, Burdwan, 713104 West Bengal India.
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