Document Detail

Correlation between Acute Coronary Syndrome Classification and Multi-detector CT Characterization of Plaque.
MedLine Citation:
PMID:  21703115     Owner:  NLM     Status:  In-Data-Review    
Objective To determine if multi-detector CT (MDCT) characterization of plaque is correlatedwith the classification of acute coronary syndrome (ACS). Methods Altogether 1900patients were examined by MDCT from December 2007 to May 2009, of whom 95patients fulfilled the criteria of ACS. Those patients were divided into thediscrete plaque group ( n=61) anddiffuse plaque group ( n=34) based onthe findings in MDCT. The clinical diagnosis of ACS and CT results wereanalyzed, including segment stenosis score, segment involvement score, 3-vesselplaque score, left main score, calcification score, and remodeling index. Theincidences of major adverse cardiac events in follow-up period were alsorecorded.ResultsThe patients of the diffuse plaque groupwere older than those of the discrete plaque group ( Pü0.0001). The diffuse plaque grouppresented more cases of hypertension, peripheral artery disease, diabetes, and heart failure than discrete plaque group (all P<0.05). All the 5 patients with ST-segment elevation myocardialinfarction were found in discrete plaque group. The segment stenosis score ofthe discrete plaque group was lower than that of the diffuse plaque group(5.15±3.55 vs. 14.91±5.37, Pü0.001). The other four scores demonstrated significant inter-group difference as well (all P<0.05). The remodeling index of thediscrete plaque group was higher (1.12±0.16 vs.0.97±0.20, Pü0.05). Follow-up data showed that major adverse cardiac eventsoccurred more frequently in diffuse plaque group than in discrete group (29.41% vs. 11.48%, P=0.0288).Conclusions Characteristics of discrete and diffuseplaques may be significantly different among different classes of ACS. Thediffuse plaque may present higher risk, correlated to higher mortality. Thediagnosis of discrete and diffuse plaques by MDCT would provide a new insightinto the prognosis and treatment of ACS.
Zhi-Guo Wang; Lu-Yue Gai; Jing-Jing Gai; Ping Li; Xia Yang; Qin-Hua Jin; Yun-Dai Chen; Zhi-Jun Sun; Zhi-Wei Guan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  26     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  China    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Department of Cardiology, The General Hospital of the People's Liberation Army, Beijing 100853, China.
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