| Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain. | |
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MedLine Citation:
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PMID: 21098179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of our study was to correlate decrease in apparent diffusion coefficient (ADC) and increase in fractional anisotropy (FA) in various white matter (WM) regions using diffusion tenor imaging (DTI) within the first year of life. MATERIALS AND METHODS: We performed DTI on 53 infants and measured FA and ADC within 10 WM regions important in brain development. For each region, we calculated the slope of ADC as a function of FA, the correlation coefficient (r) and correlation of determination (r(2)). We performed a group analysis of r values and r(2)values for six WM regions primarily composed of crossing fibers and four regions primarily having parallel fibers. Upon finding that a strong correlation of FA with age existed, we adjusted for age and calculated partial correlation coefficients. RESULTS: Slopes of FA versus ADC ranged from -1.00711 to -1.67592 (p < 0.05); r values ranged from -0.81 to -0.50 and r(2) values from 0.25 to 0.66. The four greatest r(2) values were within WM regions having large numbers of crossing fibers and the three lowest r(2) values were in regions having predominantly parallel fibers. After adjusting for age, slopes ranged from -1.08095 to 0.09612 (p < 0.05 in five cases); partial correlation coefficients ranged from -0.49 to 0.03 and r(2) values from 0.31 to 0.79. The highest partial correlation coefficients were then relatively equally distributed between the two types of WM regions. CONCLUSION: In various regions, FA and ADC evolved with differing degrees of correlation. We found a strong influence of age on the relationship between FA and ADC. |
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Authors:
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James M Provenzale; Jared Isaacson; Steven Chen; Sandra Stinnett; Chunlei Liu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 195 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-11 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: W456-62 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anisotropy Brain / growth & development* Diffusion Magnetic Resonance Imaging / methods* Humans Image Processing, Computer-Assisted Infant Infant, Newborn |
| Grant Support | |
ID/Acronym/Agency:
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R00 EB007182/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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