| Correlation of angiographic morphology immediately after coronary balloon angioplasty with coronary vasomotion late after angioplasty. | |
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MedLine Citation:
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PMID: 15193824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Various vasomotor responses to acetylcholine have been observed after coronary angioplasty. However, the relationship between the grade of vascular injury due to balloon angioplasty and vasomotor response to acetylcholine in the chronic stage is unknown. In this study we examined the correlation between the morphology immediately after coronary angioplasty and the vasomotor response to acetylcholine 1 year after angioplasty. METHODS: Thirty nine patients with a total of 45 coronary lesions without restenosis 1 year after angioplasty were studied. The 45 lesions were divided into two groups according to the morphology immediately after angioplasty. Group A comprised smooth-walled dilation and smooth-walled dilation with intraluminal haziness which were considered to be related to injury limited to the intima or the surface of the media. Group B comprised intraluminal and extraluminal haziness and extraluminal type dissection which were considered to be related to extensive medial injury. In the 39 patients, acetylcholine provocation test was performed. RESULTS: Transient total occlusion of angioplasty site was induced by acetylcholine in four lesions only in Group A. Percent change in coronary diameter after acetylcholine injection relative to that after injection of isosorbide dinitrate at the angioplasty site was larger in Group A than that of Group B. CONCLUSION: In the chronic stage, vessels with minor vascular injury exhibited a large vasomotor response to acetylcholine; conversely, the response was low in vessels with severe vascular injury by angioplasty. These observations suggest that severe vascular injury by balloon angioplasty may control coronary vasomotion in the chronic stage. |
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Authors:
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Yasuo Sutani; Hiroshi Kamihata; Syuji Ueda; Yoshihiro Yamamoto; Toshiji Iwasaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 95 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-14 Completed Date: 2004-09-17 Revised Date: 2006-07-12 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 223-9 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, Department of Medicine II, Kansai Medical University, 10-15 Fumizonocho, Moriguchi City, Osaka 570-8507, Japan. sutaniy@takii.kmu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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diagnostic use Angioplasty, Transluminal, Percutaneous Coronary / adverse effects* Coronary Angiography Coronary Vessels / injuries*, pathology Endothelium, Vascular / injuries*, pathology Female Follow-Up Studies Humans Male Middle Aged Vasoconstriction* Vasodilation* |
| Chemical | |
Reg. No./Substance:
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51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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