Document Detail

Correlation of the activity of the autonomic nervous system and the endothelial function in patients after an acute coronary syndrome.
MedLine Citation:
PMID:  25104470     Owner:  NLM     Status:  Publisher    
INTRODUCTION Endothelium and sympathetic nervous system play important role in pathogenesis of acute coronary syndrome. OBJECTIVES The aim of our study was to evaluate correlation of non-invasive markers of the endothelial function and of the sympathetic nervous system in patients after a recent ACS. PATIENTS AND METHODS The study comprised 52 patients 3 to 6 months after an ACS. The endothelial function was expressed as reactive hyperemia index (RHI). The activity of the sympathetic nervous system was expressed as latency and amplitude of sympathetic skin response (SSR) potentials from the four limbs. Linear correlation and partial correlation between RHI and SSR parameters were calculated. RESULTS There was a significant correlation between the RHI and the latency of the SSR in the upper limbs: (r=0.34, P=0.02) for the right limb and (r=0.34, P=0.01) for the left limb, respectively. After eliminating the effects of age, sex, weight, and glomerular filtration rate (GFR), partial correlation between the RHI and the latency of the SSR in the upper limbs remained statistically significant: (r=0.41, P=0.004) for the right limb and (r=0.42, P=0.004) for the left limb, respectively. There was no correlation of the RHI with the latency of the SSR during the stimulation of the lower limbs. CONCLUSIONS Study confirms the interaction of the sympathetic autonomic nervous system and of the endothelium in patients after ACS. The correlation of the RHI with the latency of the SSR was limited only in the upper limbs.  
Urszula I Cieślik-Guerra; Michał Fila; Marek Kamiński; Rafał Kotas; Janusz Wróblewski; Ewa Trzos; Barbara Uznańska-Loch; Tomasz Rechciński; Karina Wierzbowska-Drabik; Jarosław D Kasprzak; Małgorzata Kurpesa
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-7
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnetrznej     Volume:  -     ISSN:  1897-9483     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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