| Correlation of actinomycin X2 to the lipid profile in static and shaken cultures of Streptomyces nasri strain YG62. | |
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MedLine Citation:
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PMID: 10581734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Streptomyces nasri strain YG62 produces a broad-spectrum antibiotic designated actinomycin X2. The influence of static and shaken incubation on the production of actinomycin X2 and lipid profiles of S. nasri strain YG62 was investigated. It was found that shaken incubation was superior to the static process for both actinomycin X2 (2-fold) and total lipids (1.6-fold). Triglyceride and phospholipid levels paralleled the actinomycin X2 production with an increase in the triglyceride (2.8-fold) and phospholipid (1.2-fold) concentrations in the shaken culture over the static incubation. Analysis of fatty acid patterns revealed the occurrence of a wide range of fatty acids (C10-C22). The mean percentage of total saturated fatty acids in shaken culture was higher than those of the static culture. The mean percentage of mono-unsaturated fatty acids was almost the same in both cultures. The mean percentage of the total polyunsaturated fatty acids in the static culture was slightly higher than that of the shaken culture. The polyunsaturated/saturated fatty acid ratio (P/S) was higher in the static culture compared with the shaken culture. A positive correlation was recorded between triglycerides, phospholipids and actinomycin X2. A negative correlation on the other hand, was found between fatty acids and actinomycin X2. |
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Authors:
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M Y el-Naggar; M A el-Kersh; A S el-Sharaky |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Microbios Volume: 100 ISSN: 0026-2633 ISO Abbreviation: Microbios Publication Date: 1999 |
Date Detail:
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Created Date: 2000-02-04 Completed Date: 2000-02-04 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0207257 Medline TA: Microbios Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 117-27 Citation Subset: IM |
Affiliation:
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Botany and Microbiology Department, Faculty of Science, Alexandria University, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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biosynthesis* Chromatography, Gas Culture Media Fatty Acids / chemistry, metabolism Lipid Metabolism* Lipids / chemistry Microbiological Techniques Oxazines / metabolism* Peptides, Cyclic / biosynthesis* Phospholipids / chemistry, metabolism Streptomyces / growth & development, metabolism* Triglycerides / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Culture Media; 0/Fatty Acids; 0/Lipids; 0/Oxazines; 0/Peptides, Cyclic; 0/Phospholipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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