Document Detail


Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on CMR measures of LV anatomy and function.
MedLine Citation:
PMID:  23153911     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The goal of this study was to assess the relationship of left ventricular (LV) trabeculae and papillary muscles (TPM) with clinical characteristics in a community-based, free-living adult cohort and to determine the effect of TPM on quantitative measures of LV volume, mass, and ejection fraction (EF).
BACKGROUND: Hypertrabeculation has been associated with adverse cardiovascular events, but the distribution and clinical correlates of the volume and mass of the TPM in a normal left ventricle have not been well characterized.
METHODS: Short-axis cine cardiac magnetic resonance images, obtained using a steady-state free precession sequence from 1,494 members of the Framingham Heart Study Offspring cohort, were analyzed with software that automatically segments TPM. Absolute TPM volume, TPM as a fraction of end-diastolic volume (EDV) (TPM/EDV), and TPM mass as a fraction of LV mass were determined in all offspring and in a referent group of offspring free of clinical cardiovascular disease and hypertension.
RESULTS: In the referent group (mean age 61 ± 9 years; 262 men and 423 women), mean TPM was 23 ± 3% of LV EDV in both sexes (p = 0.9). TPM/EDV decreased with age (p < 0.02) but was not associated with body mass index. TPM mass as a fraction of LV mass was inversely correlated with age (p < 0.0001), body mass index (p < 0.018), and systolic blood pressure (p < 0.0001). Among all 1,494 participants (699 men), LV volumes decreased 23%, LV mass increased 28%, and EF increased by 7.5 EF units (p < 0.0001) when TPM were considered myocardial mass rather than part of the LV blood pool.
CONCLUSIONS: Global cardiac magnetic resonance LV parameters were significantly affected by whether TPM was considered as part of the LV blood pool or as part of LV mass. Our cross-sectional data from a healthy referent group of adults free of clinical cardiovascular disease demonstrated that TPM/EDV decreases with increasing age in both sexes but is not related to hypertension or obesity.
Authors:
Michael L Chuang; Philimon Gona; Gilion L T F Hautvast; Carol J Salton; Susan J Blease; Susan B Yeon; Marcel Breeuwer; Christopher J O'Donnell; Warren J Manning
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JACC. Cardiovascular imaging     Volume:  5     ISSN:  1876-7591     ISO Abbreviation:  JACC Cardiovasc Imaging     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-05-09     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101467978     Medline TA:  JACC Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1115-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Affiliation:
NHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Blood Pressure
Body Mass Index
Cross-Sectional Studies
Female
Heart Ventricles / anatomy & histology*
Humans
Hypertension / pathology,  physiopathology
Image Interpretation, Computer-Assisted
Linear Models
Magnetic Resonance Imaging, Cine*
Male
Middle Aged
Observer Variation
Papillary Muscles / anatomy & histology*,  physiology*
Predictive Value of Tests
Reference Values
Reproducibility of Results
Sex Factors
Stroke Volume
Ventricular Dysfunction, Left / pathology,  physiopathology
Ventricular Function, Left*
Grant Support
ID/Acronym/Agency:
N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01 HL070279/HL/NHLBI NIH HHS; R01 HL70279/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
JACC Cardiovasc Imaging. 2012 Nov;5(11):1124-6   [PMID:  23153912 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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