| Correlation of a scintigraphic pulmonary perfusion index with hemodynamic parameters in patients with pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 20562729 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To determine whether the perfusion index (PI) can be used as a noninvasive measure to diagnose and predict the severity of disease in patients with pulmonary arterial hypertension (PAH). MATERIALS AND METHODS: Twenty-two patients were included in this retrospective investigation: 9 controls and 13 patients with PAH. Controls had no evidence of PAH [mean pulmonary arterial pressure (MPAP) ≤25 mm Hg and pulmonary capillary wedge pressure ≤18 mm Hg]. The study patients had PAH (MPAP ≥25 mm Hg and pulmonary capillary wedge pressure ≤18 mm Hg) and no diagnosis of pulmonary embolism. Due to the retrospective nature of the study, the PI was calculated from the posterior perfusion image of a ventilation perfusion scan. The PI was computed as the sum of differences versus control for the 9 deciles above background. Receiver operating characteristic curve analysis was used to compare PI with other parameters for predicting PAH. RESULTS: Linear correlations of PI were found to be significant with the following parameters: pulmonary vascular resistance (r=0.81, P=0.00009), total pulmonary vascular resistance (MPAP/cardiac output) (r=0.80, P=0.00013), pulmonary artery systolic pressure (r=0.73, P=0.00018), MPAP (r=0.72, P=0.00022), pulmonary diastolic pressure (r=0.53, P=0.01), and right atrial pressure (r=0.50, P=0.03). Using logistic regression, the PI was significant in separating patients with PAH from controls (χ²=5.6, P=0.02). CONCLUSION: The data suggest that PI can be used for the noninvasive diagnosis and measurement of severity of PAH. |
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Authors:
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Arunabh Talwar; Pralay Sarkar; Nick Patel; Rakesh Shah; Barry Babchyck; Christopher J Palestro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of thoracic imaging Volume: 25 ISSN: 1536-0237 ISO Abbreviation: J Thorac Imaging Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606160 Medline TA: J Thorac Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 320-5 Citation Subset: IM |
Affiliation:
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Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, North Shore University Hospital, New Hyde Park, NY 11040, USA. Arunabh@NSHS.EDU |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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