Document Detail

Correlation of ST-segment "hump sign" during exercise testing with impaired diastolic function of the left ventricle.
MedLine Citation:
PMID:  19815230     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The appearance of a discrete upward deflection of the ST segment, termed the ST hump sign during exercise testing has been associated with resting hypertension and exaggerated blood pressure response to exercise. OBJECTIVE: We investigated the correlation between the presence of hump sign during exercise testing with coexisting impaired diastolic function of the left ventricle (LV) at these patients. METHODS: We formed a cohort of 237 nonconsecutive patients (140 males, 41 +/- 5 years old) having undergone a treadmill test, according to the Bruce protocol, which divided into 2 groups: group A, including 130 patients which presented ST-segment hump sign at any of the leads of the electrocardiograms recorded during exercise, and group B, including 107 patients that didn't. All patients subsequently underwent an echocardiographic estimation of the LV diastolic function, using conventional and Tissue Doppler Imaging techniques. RESULTS: From 237 patients included in our study, 106 had echocardiographic signs of diastolic LV dysfunction. Among them, the appearance of ST hump sign at the peak of exercise testing was observed in 93 patients (88%), particularly in the inferior and lateral leads, while no ST hump sign was observed only in 13 patients (12%) with impaired diastolic LV function. CONCLUSIONS: The appearance of ST segment hump sign during exercise testing is strongly correlated with diastolic LV dysfunction and can be used as an exercise electrocardiographic index of diastolic LV dysfunction, independently from the echocardiographic study.
Andreas P Michaelides; Leonidas G Raftopoulos; Constantina Aggeli; Charalambos Liakos; Charalambos Antoniades; Christos Fourlas; Elias Stamatopoulos; Nikolaos Ioakeimides; Dimitrios Soulis; Christodoulos Stefanadis
Publication Detail:
Type:  Journal Article     Date:  2009-10-07
Journal Detail:
Title:  Journal of electrocardiology     Volume:  43     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
A' Department of Cardiology, University of Athens, Hippokration Hospital, Athens, Greece.
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MeSH Terms
Electrocardiography / methods*
Exercise Test
Hypertension / complications*,  diagnosis*
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Ventricular Dysfunction, Left / complications*,  diagnosis*

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