| Correlation of P-selectin and lipoprotein(a), and other lipid parameters in preeclampsia. | |
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MedLine Citation:
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PMID: 12049188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preeclampsia is a pregnancy specific disorder and is thought to be associated with generalized endothelial dysfunction. P-selectin, an adhesion molecule, mediates the interaction of monocytes, platelets, and endothelial cells. Increased P-selectin levels and altered lipid and lipoprotein metabolism were reported in preeclampsia and during pregnancy. In order to investigate the relationship between serum P-selectin and lipoprotein(a), and other lipid parameters, 28 preeclampsia [13 severe (group I) and 15 mild preeclampsia (group II), 15 healthy pregnant (group III) and 20 non-pregnant (group IV)] women were investigated. Serum P-selectin, lipoprotein(a), total cholesterol, triglyceride, and high density lipoprotein cholesterol were measured and low-density lipoprotein cholesterol was derived. Serum P-selectin concentrations were consistently and significantly higher in the severe preeclampsia group than in the mild preeclampsia, healthy pregnancy, and non-pregnant control groups (P<0.0001, for all). The mild preeclampsia group also had increased serum P-selectin concentrations compared with the healthy pregnancy group and non-pregnant controls (P<0.05 and P<0.0001, respectively). Serum P-selectin and lipoprotein(a) levels revealed a significant and linear increase with the severity of preeclampsia. There were also significant (in groups I and II) and borderline (in groups III and IV) correlations between P-selectin and total cholesterol. The present study suggests that P-selectin may be an additional risk marker for preeclampsia, and may be useful in distinguishing women with mild and severe preeclampsia and normal pregnancy. |
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Authors:
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H Aksoy; Y Kumtepe; F Akçay; A K Yildirim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental medicine Volume: 2 ISSN: 1591-8890 ISO Abbreviation: Clin. Exp. Med. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-06-06 Completed Date: 2003-02-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100973405 Medline TA: Clin Exp Med Country: Italy |
Other Details:
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Languages: eng Pagination: 39-43 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, School of Medicine, Atatürk University, Erzurum, Turkey. aksoyhulya@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol, HDL / blood Cholesterol, LDL / blood Female Gestational Age Humans Lipoprotein(a) / blood* P-Selectin / blood* Pre-Eclampsia / blood* Pregnancy Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoprotein(a); 0/P-Selectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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