Document Detail

Correlation of P-selectin and lipoprotein(a), and other lipid parameters in preeclampsia.
MedLine Citation:
PMID:  12049188     Owner:  NLM     Status:  MEDLINE    
Preeclampsia is a pregnancy specific disorder and is thought to be associated with generalized endothelial dysfunction. P-selectin, an adhesion molecule, mediates the interaction of monocytes, platelets, and endothelial cells. Increased P-selectin levels and altered lipid and lipoprotein metabolism were reported in preeclampsia and during pregnancy. In order to investigate the relationship between serum P-selectin and lipoprotein(a), and other lipid parameters, 28 preeclampsia [13 severe (group I) and 15 mild preeclampsia (group II), 15 healthy pregnant (group III) and 20 non-pregnant (group IV)] women were investigated. Serum P-selectin, lipoprotein(a), total cholesterol, triglyceride, and high density lipoprotein cholesterol were measured and low-density lipoprotein cholesterol was derived. Serum P-selectin concentrations were consistently and significantly higher in the severe preeclampsia group than in the mild preeclampsia, healthy pregnancy, and non-pregnant control groups (P<0.0001, for all). The mild preeclampsia group also had increased serum P-selectin concentrations compared with the healthy pregnancy group and non-pregnant controls (P<0.05 and P<0.0001, respectively). Serum P-selectin and lipoprotein(a) levels revealed a significant and linear increase with the severity of preeclampsia. There were also significant (in groups I and II) and borderline (in groups III and IV) correlations between P-selectin and total cholesterol. The present study suggests that P-selectin may be an additional risk marker for preeclampsia, and may be useful in distinguishing women with mild and severe preeclampsia and normal pregnancy.
H Aksoy; Y Kumtepe; F Akçay; A K Yildirim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental medicine     Volume:  2     ISSN:  1591-8890     ISO Abbreviation:  Clin. Exp. Med.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-06     Completed Date:  2003-02-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100973405     Medline TA:  Clin Exp Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Department of Biochemistry, School of Medicine, Atatürk University, Erzurum, Turkey.
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MeSH Terms
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Gestational Age
Lipoprotein(a) / blood*
P-Selectin / blood*
Pre-Eclampsia / blood*
Statistics as Topic
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoprotein(a); 0/P-Selectin

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