Document Detail

Correlation of NT-proBNP with diastolic left ventricular function in elderly patients with ischemic stroke.
MedLine Citation:
PMID:  19101051     Owner:  NLM     Status:  MEDLINE    
We tested the hypothesis that, in elderly survivors of ischemic stroke, high NT-proBNP levels are related with frequent diastolic dysfunction. We prospectively measured NT-proBNP, left ventricular ejection fraction (LVEF) and echographic parameters of diastolic function in 55 elderly consecutive patients, 6.8+/-2.6 days after acute ischemic stroke. We found that all the patients had systolic or diastolic dysfunction (14 had LVEF<50%, 26 mild diastolic dysfunction+LVEF > or = 50%, and 15 moderate or severe diastolic dysfunction+LVEF > or = 50%). The most powerful predictors of NT-proBNP were LVEF (R=0.38, p=0.004) and ratio of mitral E to the early diastolic velocity of the mitral annulus:E/E'(R=0.34, p=0.01).
Pierre Ambrosi; Silvia Singeorzan; Christiane Oddoze; St?phane Arques; Marc Heim
Publication Detail:
Type:  Letter     Date:  2008-12-19
Journal Detail:
Title:  International journal of cardiology     Volume:  140     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  126-8     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Aged, 80 and over
Brain Ischemia / blood*,  physiopathology*
Diastole / physiology
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Prospective Studies
Ventricular Dysfunction, Left / blood*
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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