Document Detail


The correlation of endoscopic and histological diagnosis of gastric atrophy.
MedLine Citation:
PMID:  19629687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Gastric atrophy is a premalignant condition. The aim of this study was to evaluate the correlation between histological and endoscopic findings of atrophy, and to analyze the affecting factors. METHODS: Atrophy was graded by endoscopy, and biopsy was performed in the antrum and body for the diagnosis of atrophy according to the Sydney system in the 1,330 subjects. RESULTS: Both endoscopic and histological atrophy increased in proportion to age (P < 0.001). The prevalence of endoscopic atrophy was significantly lower than that of histological atrophy especially below 50 years of age. The sensitivity and specificity of endoscopy for the diagnosis of atrophy based on histological diagnosis of atrophy were 61.5 and 57.7% in the antrum, and were 46.8 and 76.4% in the body of the stomach. Multivariate analysis showed that an age <50 (OR 0.38, 95% CI 0.25-0.61) and a PG I/II ratio >3 (OR 0.50, 95% CI 0.35-0.71) in the antrum, and an age < 50 (OR 0.43, 95% CI 0.19-1.00) and a CRP > 5 mg/dl (OR 0.53, 95% CI 0.30-0.94) decreased the sensitivity of the endoscopic diagnosis of atrophy in the body. CONCLUSIONS: A high index of suspicion of gastric atrophy is important in the young age group, and confirmation of the diagnosis by histology is necessary.
Authors:
Alisher Eshmuratov; Jong Chun Nah; Nayoung Kim; Hye Seung Lee; Hee Eun Lee; Byoung Hwan Lee; Min Sik Uhm; Young Soo Park; Dong Ho Lee; Hyun Chae Jung; In Sung Song
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Publication Detail:
Type:  Journal Article     Date:  2009-07-23
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1364-75     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Gyeonggi-do 463-707, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Biopsy
Chi-Square Distribution
Female
Gastritis, Atrophic / diagnosis*,  pathology
Gastroscopy
Helicobacter Infections / diagnosis
Helicobacter pylori
Humans
Logistic Models
Male
Middle Aged
Pepsinogen A / blood
Risk Factors
Sensitivity and Specificity
Chemical
Reg. No./Substance:
9001-10-9/Pepsinogen A
Comments/Corrections
Comment In:
Dig Dis Sci. 2010 Jun;55(6):1799-800   [PMID:  19802697 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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