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The Correlation of Biochemical and Morphologic Parameters in the Assessment of Sperm Maturity.
MedLine Citation:
PMID:  24094663     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To examine the relationship between biochemical markers and morphologic sperm characteristics, including head, neck, and tail changes.
METHODS: The study evaluated 154 patients who went to the Andrology Laboratory of the Clinic of Urology, Clinical Center of Serbia. Patients were divided into 4 groups: normozoospermic, oligozoospermic, severe oligozoospermic, and asthenozoospermic, according to the sperm concentration and motility.
RESULTS: The differences in creatine kinase (CK) and CK-M levels between normozoospermic and the 2 groups of oligozoospermic patients were significantly different (P <.01). The CK and CK-M levels correlated negatively with sperm concentration and sperm motility, but correlated positively with the pathologic sperm form. Patients with CK values >0.093 have a total number of pathologic forms higher than 0.40 (87.5% sensitivity, 77.3% specificity, the area under the curve was 0.832, P <.001). Patients with CK values <0.09 U/L have normal spermatogenesis and pathologic disorder of the head <15%, neck <12%, and tail <10%.
CONCLUSION: The relation between sperm morphology and biochemical markers included in the maturation process is established during the sperm genesis process. If the results of these markers are used together with the morphology of the spermatozoa in the interpretation of infertility, it would lead us to better insight of the fertility potential of the each patient.
Authors:
Otas Durutovic; Natasa Lalic; Dragica Milenkovic-Petronic; Nebojsa Bojanic; Dejan Djordjevic; Bogomir Milojevic; Nebojsa Ladjevic; Ana Mimic; Lidija Tulic; Zoran Dzamic; Sava Micic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-2
Journal Detail:
Title:  Urology     Volume:  -     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Clinic of Urology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine University of Belgrade, Belgrade, Serbia.
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