| Correlation between imatinib pharmacokinetics and clinical response in Japanese patients with chronic-phase chronic myeloid leukemia. | |
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MedLine Citation:
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PMID: 20980997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the outstanding results generally obtained with imatinib mesylate (IM) in the treatment of chronic myeloid leukemia (CML), some patients show a poor molecular response. To evaluate the relationship between steady-state trough plasma IM concentration (IM-C(min)) and clinical response in CML patients, we integrated data from six independent Japanese studies. Among 254 CML patients, the mean IM-C(min) was 1,010.5 ng/ml. Importantly, IM-C(min) was significantly higher in patients who achieved a major molecular response (MMR) than in those who did not (P = 0.002). Multivariate analysis showed that an MMR was associated with both age (odds ratio (OR) = 0.97 (0.958-0.995); P = 0.0153) and with IM-C(min) (OR = 1.0008 (1.0003-1.0015); P = 0.0044). Given that patients with IM-C(min) values >1,002 ng/ml had a higher probability of achieving an MMR in our large cohort (P = 0.0120), the data suggest that monitoring of IM levels in plasma may improve the efficacy of IM therapy for CML patients. |
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Authors:
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N Takahashi; H Wakita; M Miura; S A Scott; K Nishii; M Masuko; M Sakai; Y Maeda; K Ishige; M Kashimura; K Fujikawa; M Fukazawa; T Katayama; F Monma; M Narita; F Urase; T Furukawa; Y Miyazaki; N Katayama; K Sawada |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study Date: 2010-10-27 |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 88 ISSN: 1532-6535 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 809-13 Citation Subset: AIM; IM |
Affiliation:
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Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan. naotot@doc.med.akita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Asian Continental Ancestry Group* Cohort Studies Female Humans Leukemia, Myeloid, Chronic-Phase / drug therapy*, metabolism* Male Middle Aged Piperazines / pharmacokinetics*, therapeutic use* Pyrimidines / pharmacokinetics*, therapeutic use* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib |
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