Document Detail


Correlation between imatinib pharmacokinetics and clinical response in Japanese patients with chronic-phase chronic myeloid leukemia.
MedLine Citation:
PMID:  20980997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the outstanding results generally obtained with imatinib mesylate (IM) in the treatment of chronic myeloid leukemia (CML), some patients show a poor molecular response. To evaluate the relationship between steady-state trough plasma IM concentration (IM-C(min)) and clinical response in CML patients, we integrated data from six independent Japanese studies. Among 254 CML patients, the mean IM-C(min) was 1,010.5 ng/ml. Importantly, IM-C(min) was significantly higher in patients who achieved a major molecular response (MMR) than in those who did not (P = 0.002). Multivariate analysis showed that an MMR was associated with both age (odds ratio (OR) = 0.97 (0.958-0.995); P = 0.0153) and with IM-C(min) (OR = 1.0008 (1.0003-1.0015); P = 0.0044). Given that patients with IM-C(min) values >1,002 ng/ml had a higher probability of achieving an MMR in our large cohort (P = 0.0120), the data suggest that monitoring of IM levels in plasma may improve the efficacy of IM therapy for CML patients.
Authors:
N Takahashi; H Wakita; M Miura; S A Scott; K Nishii; M Masuko; M Sakai; Y Maeda; K Ishige; M Kashimura; K Fujikawa; M Fukazawa; T Katayama; F Monma; M Narita; F Urase; T Furukawa; Y Miyazaki; N Katayama; K Sawada
Related Documents :
10910927 - Tel/aml1 gene fusion is related to in vitro drug sensitivity for l-asparaginase in chil...
10849527 - Mobilisation of haemopoietic progenitors in cml: a second course of intensive chemother...
20692037 - The use of imatinib mesylate has no adverse effects on the heart function. results of a...
20671427 - Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia.
153577 - Mobile arm supports: an evaluation.
21692937 - Correlation between promoter methylation of glutathione-s-tranferase p1 and oxidative s...
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2010-10-27
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  88     ISSN:  1532-6535     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  809-13     Citation Subset:  AIM; IM    
Affiliation:
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan. naotot@doc.med.akita-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group*
Cohort Studies
Female
Humans
Leukemia, Myeloid, Chronic-Phase / drug therapy*,  metabolism*
Male
Middle Aged
Piperazines / pharmacokinetics*,  therapeutic use*
Pyrimidines / pharmacokinetics*,  therapeutic use*
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes.
Next Document:  Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones...