Document Detail

Correlation Between Hyperhomocysteinemia and Outcomes of Patients With Acute Myocardial Infarction.
MedLine Citation:
PMID:  25405897     Owner:  NLM     Status:  Publisher    
Overwhelming clinical and epidemiological studies have identified elevated plasma total homocysteine (Hcy) as new important risk factor for atherosclerotic vascular disease. But the relationship between outcome and hyperhomocysteinemia in patients with acute myocardial infarction (AMI) has been rarely reported. This study aimed to evaluate the association between hyperhomocysteinemia and short-term outcomes of patients with AMI. Eight hundred five patients were divided into high Hcy level group (group H: N = 457) and low Hcy level group (group L: N = 348) according to the plasma Hcy levels of 15 mmol/L. The comparisons were made between 2 groups in the following aspects: sex, hypertension, diabetes, hyperlipidemia, the time for symptom from onset to percutaneous coronary intervention, homoccyteine, creatine phosphokinase isoenzyme (creatine kinase myocardial band), and the incidence of 30-day adverse events. The incidences of heart failure, cardiac rupture, death, and the total adverse cardiovascular events were statistically significantly higher in group H than in group L. But the incidence of postoperative angina pectoris and reinfarction was similar between groups. The results of logistic regression showed that the incidence of 30-day adverse events was closely related to the age and the level of Hcy. An elevated plasma total Hcy level in patients with AMI experienced pemutaneous coronary intervention may be related to the short-term outcomes. An elevated high plasma Hcy level also seems to be an independent predictor of 30-day cardiovascular events in patients with AMI.
Yi Ma; Li Li; Xue-Bin Geng; Ye Hong; Xiao-Ming Shang; Zheng Tan; Yu-Xin Song; Guo-Yu Zhao; Bi-Qiong Zhao; Mei-Rong Tian
Related Documents :
19104727 - Fdg-pet and mibi-tc spect as follow-up tools in a patient with cardiac sarcoidosis requ...
19684037 - Autopsy and clinical context in deceased patients with implanted pacemakers and defibri...
1393747 - Temporary transvenous cardiac pacing.
11104407 - Indications for cardiac pacemaker implantation in myotonic dystrophy.
16483337 - Sirolimus-versus paclitaxel-eluting stents: a comparison of two consecutive series in r...
2634107 - The type a city: coronary heart disease and the pace of life.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-17
Journal Detail:
Title:  American journal of therapeutics     Volume:  -     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-18     Completed Date:  -     Revised Date:  2014-11-19    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Type B Lactic Acidosis Associated With Venlafaxine Overdose.
Next Document:  MicroRNA in neurodegenerative drug discovery: the way forward?