| Correlation between HLA and posttransplantation diabetes mellitus in the Han population in South China. | |
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MedLine Citation:
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PMID: 20832533 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Posttransplantation diabetes mellitus (PTDM) is a common metabolic complication in renal transplant recipients. Some studies have revealed predisposing or protective HLA genes for PTDM. OBJECTIVE: To describe the characteristics of PTDM in patients in the south of China. METHODS: The present study included 195 living-donor kidney transplant recipients. Informed consent was obtained from all participants, and the study was approved by our Institutional Ethics Committee. Each donor-recipient pair was related. Twenty-two patients had PTDM, whereas 173 did not. The frequency of each HLA phenotype was compared between these 2 groups. The 195 patients were divided into 2 groups according to immunosuppression regimen, a cyclosporine group and a tacrolimus group, and the incidence of PTDM was compared between the groups. Patients were then subdivided into 2 groups according to age, an elderly group (age 40 years or older) and a younger group (age younger than 40 years), and the incidence of PTDM was calculated and compared between these 2 groups. RESULTS: HLA-A30 and HLA-DR7 seem to be predisposing genes for PTDM in patients in the south of China; Low dosages of calcineurin inhibitors were used in our center, There was no significant difference in the incidence of PTDM between the CsA and Tac groups; The incidence of PTDM in the elderly group was significantly higher than that in the younger group. CONCLUSION: Patients receiving HLA-A30 and HLA-DR7 antigens, and elderly patients are at higher risk of developing PTDM. Tacrolimus does not significantly increase the incidence of PTDM. |
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Authors:
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S J Yu; L Peng; X B Xie; F H Peng; C H Fang; Y Wang; G B Lan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2509-12 Citation Subset: IM |
Copyright Information:
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2010. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Second Xiang-Ya Hospital, Central South University, Changsha, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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