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Correlation Between the Distribution of SP and CGRP Immunopositive Neurons in Dorsal Root Ganglia and the Afferent Sensation of Preputial Frenulum.
MedLine Citation:
PMID:  21337713     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aim of this study was to explore the distribution of substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactive nerve terminals in the penis prepuce and the preputial frenulum. The possible correlation between SP- and CGRP-immunopositive neurons in dorsal root ganglia (DRG) and the afferent sensation of the penile preputial frenulum is also discussed. Immunohistochemistry showed SP- and CGRP-positive nerve terminals in the epidermal basal layer of the prepuce and frenulum in adult human males. The majority of the nerve terminals presented as bundles of different lengths and a few as enlarged nodosities. The density of SP- and CGRP-immunopositive nerve terminals in the preputial frenulum was significantly higher than those in the penis prepuce (P<0.01). Fluoro-Gold (FG) retrograde tracing method was used to trace the origin of nerve terminals in Sprague-Dawley rats. SP and CGRP immunofluorescence labeling was employed to detect the distribution of SP- and CGRP-immunoreactive neurons in DRG. FG retro-labeled neurons were localized in L(6) -DRG and S(1) -DRG. All the FG/SP and FG/CGRP double-labeled neurons were medium or small-sized. One-third of the FG-labeled neurons were SP-immunoreactive, and a half of them CGRP-immunoreactive in L(6) -DRG and S(1) -DRG, respectively. The FG/SP/CGRP-labeled neurons accounted for one fifth of the FG retro-labeled neurons. Taken together, these data suggest that the SP- and CGRP-immunopositive nerve fibers may participate in the transmission of afferent sensation in the preputial frenulum. Anat Rec, 2011. © 2010 Wiley-Liss, Inc.
Authors:
Zhong-Min Wu; Yong-Feng Chen; Peng-Nian Qiu; Shu-Cai Ling
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Publication Detail:
Type:  Journal Article     Date:  2010-12-31
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  294     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Affiliation:
Department of Anatomy, School of Medicine of Zhejiang University, Hangzhou, China; Department of Anatomy, School of Medicine of Taizhou University, Taizhou, China.
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