Document Detail

Correlation between the degree of air trapping in chest HRCT and cardiopulmonary exercise test parameters: could HRCT be a predictor of disease severity?
MedLine Citation:
PMID:  21361713     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to examine whether the degree of air trapping in high resolution computed tomography (HRCT) of patients with histories of sulfur mustard gas exposure during suspended full expiration correlated with various parameters of the cardiopulmonary exercise test as the gold standard for assessment of pulmonary function.
METHODS: In this analytic study 75 male patients, each with a history of sulfur mustard gas exposure, were investigated. Each participant underwent an incremental cardiopulmonary exercise test, pulmonary function test and arterial oxygen saturation for hemoglobin measurement. For HRCT examination, both lungs were divided into three parts (upper, middle, and lower) and in each part images were separately observed from the involved area point of view (<25% ≤6/24; >25% ≥6/24).
RESULTS: A total of 49.3% of the patients (37/75) had evidence of air trapping in over 25% of their lung segments. The mean age±SD in the patients with air trapping of =25% or <25% were 41.1±6.8 and 39.7±4.0 years, respectively (P=0.281). In our study there was no significant difference in pulmonary function test findings (FEV1, FVC and FEV1/FVC) between the two groups. There was no significant correlation with air trapping of =25% and any of the exercise test parameters. Also, no correlation was found between significant air trapping and exercise test findings in maximum exercise and anaerobic situations.
CONCLUSIONS: No correlation was found between HRCT and cardiopulmonary exercise test findings. HRCT is neither pathognomic of the disease nor a good predictor of disease severity but it might be suggestive of mustard lung injuries.
Mostafa Ghanei; Mohsen Sheyacy; Mohammad Amin Abbasi; Alireza Ani; Jafar Aslani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  14     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-07-22     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Chemical Warfare Agents / adverse effects
Chronic Disease
Exercise Test
Lung Diseases / chemically induced,  physiopathology,  radiography*
Middle Aged
Mustard Gas / adverse effects
Respiratory Function Tests*
Severity of Illness Index*
Tomography, X-Ray Computed*
Reg. No./Substance:
0/Chemical Warfare Agents; 505-60-2/Mustard Gas
Comment In:
Arch Iran Med. 2011 Mar;14(2):84-5   [PMID:  21361712 ]

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