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The Correlation Between Coronary Plaque Phenotype and Carotid Atherosclerotic Plaque Composition.
MedLine Citation:
PMID:  21681073     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION:: Studies have shown that atherosclerosis in coronary arteries is closely related to that in carotid arteries, but there are few investigations on the correlation between unstable plaques in these 2 vascular beds. The authors aim to investigate the correlation between coronary plaque phenotype and carotid plaque composition. METHODS:: Patients (n = 123) with suspected coronary artery disease underwent computed tomography angiography of coronary arteries. Magnetic resonance imaging of bilateral carotid arteries was performed within 2 weeks after computed tomography angiography. The plaque type in each coronary segment was analyzed. Coronary plaques were classified into 3 types: noncalcified, calcified and mixed. The total number of each plaque type was scored. Carotid plaque with calcification, lipid-rich necrotic core (LRNC) or intraplaque hemorrhage (IPH) in either carotid artery was defined as positive. Logistic regression analysis was used to determine the correlation between coronary plaque phenotype and carotid plaque composition. The area under the receiver-operating characteristic curve (AUC) was calculated. RESULTS:: There was a significant correlation between the mixed coronary plaque score and carotid IPH (odds ratio = 1.50, P < 0.05). The scores for all 3 types of the coronary plaque were significantly correlated with carotid LRNC and calcification. The mixed coronary plaque score had the highest value in predicting carotid IPH (AUC = 0.74). The calcified coronary plaque score showed the highest value in predicting carotid LRNC (AUC = 0.75) and calcification (AUC = 0.75). CONCLUSION:: There was significant correlation between coronary plaque phenotype and carotid plaque composition. A mixed coronary plaque may be suggestive of a high-risk carotid plaque.
Authors:
Qian Zhao; Xihai Zhao; Zulong Cai; Feiyu Li; Chun Yuan; Jianming Cai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-15
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Radiology (qz), The Military General Hospital of Beijing of PLA; Department of Radiology (qz, zc, jc), Chinese PLA General Hospital; Center for Bio-Medical Imaging Research (xz), Tsinghua University School of Medicine; Department of Radiology (fl), Peking University Hospital, Beijing, China; and Department of Radiology (cy), University of Washington, Seattle, Washington.
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