| Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 22354195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up. METHODS AND RESULTS: Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive C-reactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. CONCLUSIONS: The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI. |
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Authors:
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Han Saem Jeong; Soon Jun Hong; Jae Hyoung Park; Jong-Ho Kim; Seung Cheol Choi; Chul-Min Ahn; Je Sang Kim; Do-Sun Lim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-02-21 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 76 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-04-25 Completed Date: 2012-08-20 Revised Date: 2012-12-19 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1213-21 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antigens, CD / blood Coronary Circulation* Cytokines / blood Female Hematopoietic Stem Cell Mobilization* Humans Male Middle Aged Myocardial Infarction / blood*, pathology, physiopathology*, therapy Prospective Studies Receptors, CXCR4 / blood Stem Cells / metabolism*, pathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CXCR4 protein, human; 0/Cytokines; 0/Receptors, CXCR4 |
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