Document Detail


Correlation between arterial FDG uptake and biomarkers in peripheral artery disease.
MedLine Citation:
PMID:  22239891     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: A prospective, multicenter (18)fluorine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging study was performed to estimate the correlations among arterial FDG uptake and atherosclerotic plaque biomarkers in patients with peripheral artery disease.
BACKGROUND: Inflammation within atherosclerotic plaques is associated with instability of the plaque and future cardiovascular events. Previous studies have shown that (18)F-FDG-PET/CT is able to quantify inflammation within carotid artery atherosclerotic plaques, but no studies to date have investigated this correlation in peripheral arteries with immunohistochemical confirmation.
METHODS: Thirty patients across 5 study sites underwent (18)F-FDG-PET/CT imaging before SilverHawk atherectomy (FoxHollow Technologies, Redwood City, California) for symptomatic common or superficial femoral arterial disease. Vascular FDG uptake (expressed as target-to-background ratio) was measured in the carotid arteries and aorta and femoral arteries, including the region of atherectomy. Immunohistochemistry was performed on the excised atherosclerotic plaque extracts, and cluster of differentiation 68 (CD68) level as a measure of macrophage content was determined. Correlations between target-to-background ratio of excised lesions, as well as entire arterial regions, and CD68 levels were determined. Imaging was performed during the 2 weeks before surgery in all cases.
RESULTS: Twenty-one patients had adequate-quality (18)F-FDG-PET/CT peripheral artery images, and 34 plaque specimens were obtained. No significant correlation between lesion target-to-background ratio and CD68 level was observed.
CONCLUSIONS: There were no significant correlations between CD68 level (as a measure of macrophage content) and FDG uptake in the peripheral arteries in this multicenter study. Differences in lesion extraction technique, lesion size, the degree of inflammation, and imaging coregistration techniques may have been responsible for the failure to observe the strong correlations with vascular FDG uptake observed in previous studies of the carotid artery and in several animal models of atherosclerosis.
Authors:
Kelly S Myers; James H F Rudd; Eric P Hailman; James A Bolognese; Joanne Burke; Cathy Anne Pinto; Michael Klimas; Richard Hargreaves; Hayes M Dansky; Zahi A Fayad
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JACC. Cardiovascular imaging     Volume:  5     ISSN:  1876-7591     ISO Abbreviation:  JACC Cardiovasc Imaging     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-13     Completed Date:  2012-05-17     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101467978     Medline TA:  JACC Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD / analysis*
Antigens, Differentiation, Myelomonocytic / analysis*
Aorta / immunology,  radionuclide imaging
Arteries / immunology*,  radionuclide imaging*
Biological Markers / analysis
Carotid Arteries / immunology,  radionuclide imaging
Feasibility Studies
Female
Femoral Artery / immunology,  radionuclide imaging
Fluorodeoxyglucose F18 / diagnostic use*
Humans
Immunohistochemistry
Male
Middle Aged
Multimodal Imaging*
Peripheral Arterial Disease / immunology*,  radiography,  radionuclide imaging*
Positron-Emission Tomography*
Predictive Value of Tests
Prospective Studies
Radiopharmaceuticals / diagnostic use*
Tomography, X-Ray Computed*
United States
Grant Support
ID/Acronym/Agency:
R01 HL071021/HL/NHLBI NIH HHS; R01 HL71021/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/Biological Markers; 0/CD68 antigen, human; 0/Radiopharmaceuticals; 0Z5B2CJX4D/Fluorodeoxyglucose F18
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