Document Detail

Correlation between argyrophilic nucleolar organizer region staining and brain tumor classification and grading.
MedLine Citation:
PMID:  20014945     Owner:  NLM     Status:  MEDLINE    
Distinctions between benign and malignant tumors are less evident in the central nervous system than in other tissues. Since the level of cell proliferation is an important feature in tumor grading, we applied AgNOR in 50 cases of brain tumors with different grades and histological origins in order to check its efficiency in discriminating between benign and malignant cases. We found significant differences between the means of grade I (1.76) and grade IV (2.46) tumors. No significant differences were observed considering the same grading with distinct histological types or age of patients, reinforcing the efficiency of AgNOR.
Luciana G Quintana; F?bio Pacheco E da Silva; Julio C Pieczarka; Cleusa Y Nagamachi; Nilson P Anselmo; Edivaldo H C de Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer investigation     Volume:  28     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-64     Citation Subset:  IM    
Instituto de Ci?ncias Biol?gicas, Universidade Federal do Par?, Bel?m, PA, Brasil.
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MeSH Terms
Age Factors
Brain Neoplasms / pathology*
Chromosomal Proteins, Non-Histone / metabolism
Middle Aged
Nucleolus Organizer Region / pathology*
Silver Staining*
Reg. No./Substance:
0/Chromosomal Proteins, Non-Histone

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