| Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland. | |
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MedLine Citation:
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PMID: 12375583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to examine the allelic frequency of the -3826A > G mutation of UPC1 in patients with familiar obesity and to investigate putative association of this polymorphism with metabolic disorders. One hundred and eighteen overweight /obese patients participated in the study. The UCP1 polymorphism was determined by RFLP. Glucose, lipid, insulin and leptin levels were measured both during OGTT and OLTT. The majority of patients had a homozygous A/A genotype (51,38%), while 14,68% had a G/G genotype. We found no significant association of the G allele with either BMI or glucose tolerance. Patients with the homozygous G/G genotype had significantly higher fasting levels of TG (p < 0.04) and decreased levels of HDL-cholesterol (p = 0,004). They also had an increased concentration of FFA and the rise of TG levels during the OLTT compared to controls was significant (p = 0,058). In addition, the carriers of the G/G genotype had the lowest insulin levels both during OGTT and OLTT. In our study we have demonstrated that the -3826A > G polymorphism of UCP1 does not play a major role in the development of obesity and/or disturbances of glucose metabolism. However, the increased levels of TG and FFA and decreased levels of HDL observed in carriers of the G allele suggest FFA-induced impairment of the HDL turnover and disturbance of the beta-cell function, both of which are risk factors for endothelial injury. |
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Authors:
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B Kieć-Wilk; I Wybrańska; M Malczewska-Malec; L Leszczyńska-Gołabek; L Partyka; S Niedbał; A Jabrocka; A Dembińska-Kieć |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 53 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-08 Completed Date: 2003-03-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 477-90 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Medical College, Jagiellonian University, Out-patient Clinic of Obesity and Lipid Disorders, Kraków, Poland. mbkiec@cyf-kr.edu.pl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Carrier Proteins / genetics* Endothelium, Vascular / physiopathology Female Glucose Tolerance Test Humans Insulin / physiology Ion Channels Lipids / blood Male Membrane Proteins / genetics* Metabolic Diseases / complications, genetics*, pathology, physiopathology Middle Aged Mitochondrial Proteins Obesity / complications, genetics*, pathology, physiopathology Platelet Activation Poland Polymorphism, Genetic / genetics* Promoter Regions, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Ion Channels; 0/Lipids; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein; 11061-68-0/Insulin |
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