Document Detail


Correlation of 2-methoxyestradiol levels in cord blood and complications of prematurity.
MedLine Citation:
PMID:  20098341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
2-methoxyestradiol (2ME2) is a potent antiangiogenic molecule that inhibits the expression of hypoxia-inducible factor (HIF)-1alpha and, consequently, of VEGF and other HIF-1alpha target genes. Although 2ME2 is elevated during pregnancy in maternal serum, its presence in fetal fluids and its impact in neonatal health are unknown. In this study, we 1) described normal levels of 2ME2 in maternal blood, cord blood, breast milk, and amniotic fluid, and 2) compared a composite measure of perinatal outcome between infants born with high and low levels of 2ME2. We found that 2ME2 was significantly decreased in all fluids compared with prepartum maternal serum. After stratifying babies by 2ME2 exposure levels, we observed no differences in the vulnerability to impaired lung development or to complications involving aberrant angiogenesis or vascular leak, such as necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), posthemorrhagic hydrocephalus (PHH), and retinopathy of prematurity (ROP). In summary, fetal 2ME2 concentrations do not appear to affect neonatal outcome.
Authors:
Carmen M Barnes; Thomas F McElrath; Judah Folkman; Anne R Hansen
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
Affiliation:
Department of Surgery, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid / metabolism
Biological Markers / blood
Estradiol / analogs & derivatives*,  blood
Female
Fetal Blood / metabolism*
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / blood,  etiology*
Male
Maternal-Fetal Exchange
Milk, Human / metabolism
Pregnancy
Reference Values
Risk Assessment
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 362-07-2/2-methoxyestradiol; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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