| Correlates of left atrial size in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study. | |
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MedLine Citation:
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PMID: 11897755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular hypertrophy has been suggested to mediate the relation between hypertension and left atrial enlargement, with associated risks of atrial fibrillation and stroke. However, less is known about correlates of left atrial size in hypertensive patients with left ventricular hypertrophy. We assessed left atrial size by echocardiography in 941 hypertensive patients, age 55 to 80 (mean, 66) years, with electrocardiographic left ventricular hypertrophy at baseline in the Losartan Intervention For Endpoint reduction in hypertension study. Enlarged left atrial diameter (women, >3.8 cm; men, >4.2 cm) was present in 56% of women and 38% of men (P<0.01). Compared with the 512 patients with normal left atrial size, the 429 patients with enlarged left atrium more often had mitral regurgitation, atrial fibrillation, and echocardiographic left ventricular hypertrophy. They also had higher age, systolic blood pressure, pulse pressure, weight, body mass index, left ventricular internal chamber dimension, stroke volume, and mass and lower relative wall thickness and ejection fraction (all, P<0.05). In logistic regression analysis, left atrial enlargement was related to left ventricular hypertrophy and eccentric geometry; greater body mass index, systolic blood pressure, and age; female gender; mitral regurgitation; and atrial fibrillation (all, P<0.05). Thus, left atrial size in hypertensive patients with electrocardiographic left ventricular hypertrophy is influenced by gender, age, obesity, systolic blood pressure, and left ventricular geometry independently of left ventricular mass and presence of mitral regurgitation or atrial fibrillation. |
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Authors:
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Eva Gerdts; Lasse Oikarinen; Vittorio Palmieri; Jan Erik Otterstad; Kristian Wachtell; Kurt Boman; Björn Dahlöf; Richard B Devereux; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 39 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-18 Completed Date: 2002-05-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 739-43 Citation Subset: IM |
Affiliation:
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Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. evgerdts@online.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Electrocardiography Female Heart Atria / pathology*, physiopathology Hemodynamics Humans Hypertension / physiopathology* Hypertrophy, Left Ventricular / physiopathology* Logistic Models Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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