| Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice. | |
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MedLine Citation:
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PMID: 2403528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Germfree athymic (nu/nu) and euthymic (nu/+) mice were colonized with a pure culture of Candida albicans. Correlates of cell-mediated immunity (lymphocyte proliferation and footpad responses to C. albicans antigens) and in vivo clearance of mucosal infections were assessed at different time intervals after alimentary tract colonization. C. albicans hyphae infected the dorsal surface of the tongue and the cardial section of the stomach in both nu/nu and nu/+ mice within 1 week after colonization with a pure culture of C. albicans. With time after colonization and infection with C. albicans, nu/+ mice manifested positive lymphocyte proliferation and positive footpad responses to Candida antigens that appeared to correlate with the capacity to clear Candida hyphae from the dorsal surface of the tongue and in the stomach. Conversely, nu/nu mice could not clear mucosal candidosis (in the stomach and on the tongue) and did not manifest either lymphocyte proliferation or footpad swelling in response to C. albicans antigens. These studies indicated that T-cell-mediated immunity may play a role in the acquired resistance of mice to mucosal candidosis. Since neither nu/nu nor nu/+ mice developed a progressive systemic disease, T cells apparently do not play a prominent role in murine resistance to systemic candidosis of endogenous origin. |
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Authors:
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E Balish; H Filutowicz; T D Oberley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection and immunity Volume: 58 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-01 Completed Date: 1990-02-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 107-13 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Wisconsin Medical School, Madison 53706. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Candida albicans / growth & development, immunology Candidiasis / immunology* Germ-Free Life Hypersensitivity, Delayed / immunology, pathology Immunity, Cellular* Lymph Nodes / microbiology Lymphocyte Activation Mice Mice, Nude Stomach / microbiology Tongue / microbiology, pathology |
| Comments/Corrections | |
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