Document Detail


Correlates of NT-proBNP concentration in patients with essential hypertension in absence of congestive heart failure.
MedLine Citation:
PMID:  20087954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: N-terminal proBNP (NT-proBNP) is widely used as a diagnostic biomarker and for the risk stratification of patients with heart failure (HF). Its role in the evaluation of patients with essential hypertension (EHT) is less clear. We examined the relationship between NT-proBNP concentrations and various clinical characteristics in hypertensive patients without HF. METHODS: This study included 186 consecutive patients with EHT and no history of HF, ischemic heart disease, or atrial fibrillation. Single and multiple variable regression analyses were performed in search of clinical correlates of NT-proBNP concentrations. RESULTS: In patients with EHT, median serum concentration of NT-proBNP was 73 pg/ml, and interquartile range (IQR) was 40-128 pg/ml. NT-proBNP was significantly higher (P<0.001) in women (87 pg/ml; IQR 55-137 pg/ml) than in men (52 pg/ml; IQR 24-115 pg/ml). Age (r=0.371, P<0.001), precordial QRS voltage (r=0.223, P<0.001), hemoglobin (Hgb) concentration, (r=-0.208, P=0.023) and estimated glomerular filtration rate (r=-0.139, P=0.044) were correlated with log-transformed NT-proBNP by multiple variable analysis. In men, age (r=0.453, P<0.001) and QRS voltage (r=0.283, P=0.004), and in women age (r=0.299, P=0.006), QRS voltage (r=0.212, P=0.019), Hgb (r=-0.182, P=0.049), and estimated glomerular filtration rate (r=-0.272, P=0.009) were correlated with serum concentrations of NT-proBNP. CONCLUSIONS: Age, gender, Hgb, left ventricular hypertrophy and renal function were correlated with NT-proBNP in patients with EHT.
Authors:
Keizo Toda; Yukihito Sato; Tomoko Hara; Kenro Hijiya; Ryutaro Kaneko; Tatuo Okada; Yoshiki Takatsu; Hisayoshi Fujiwara; Toshiaki Iwasaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  24     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-25     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, Hyogo Prefecture Amagasaki Hospital, Hyogo, Japan. amag_scgisi_02@pref.hyogo.lg.jp
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Biological Markers / blood
Electrocardiography
Female
Glomerular Filtration Rate
Heart Failure / blood
Hemoglobins / metabolism
Humans
Hypertension / blood*
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Regression Analysis
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobins; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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