| Correlates of N-terminal prohormone brain natriuretic peptides in African Americans with hypertensive chronic kidney disease: the African American Study of Kidney Disease and Hypertension. | |
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MedLine Citation:
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PMID: 18824845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The N-amino-terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) is a marker of cardiac stress and elevated levels are indicative of heart failure. Few correlates of NT-proBNP levels have been identified in persons with moderate chronic kidney disease (CKD), and data from those without heart failure and from African Americans are especially limited. METHODS: The African American Study of Kidney Disease and Hypertension (AASK) enrolled nondiabetic African Americans with hypertensive kidney disease (glomerular filtration rate [GFR] = 20-65 ml/min/1.73 m(2)) and no evidence of clinical heart failure. NT-proBNP was measured in 982 AASK participants. RESULTS: In unadjusted analyses, GFR (r = -0.39; p < 0.001), hematocrit (r = -0.21; p < 0.001) and body mass index (BMI; r = -0.07; p = 0.04) were inversely correlated, and systolic blood pressure (r = 0.30; p < 0.001) and log UPCR (r = 0.32; p < 0.001) were positively correlated with log NT-proBNP levels. After adjustment for potential confounders, lower GFR and hematocrit and higher systolic blood pressure and protein:creatinine ratio remained significantly associated with higher NT-proBNP. CONCLUSION: Lower GFR and hematocrit, and higher urinary protein excretion may be associated with volume expansion in CKD. These results suggest that these processes are associated with increased NT-proBNP in CKD and may play a role in the development of heart failure. |
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Authors:
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S Yi; G Contreras; E R Miller; L J Appel; B C Astor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-09-29 |
Journal Detail:
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Title: American journal of nephrology Volume: 29 ISSN: 1421-9670 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-27 Completed Date: 2009-05-21 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 292-8 Citation Subset: IM |
Affiliation:
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Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Md., USA. ssyi@jhsph.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans / statistics & numerical data* Aged Body Mass Index Creatinine / urine Female Glomerular Filtration Rate Heart Failure / blood, ethnology Hematocrit Humans Hypertension, Renal / blood*, ethnology* Male Middle Aged Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Proteinuria / blood, ethnology Renal Insufficiency, Chronic / blood*, ethnology* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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2P20 R11104//PHS HHS; 5M01 RR00071/RR/NCRR NIH HHS; DK2818-02./DK/NIDDK NIH HHS; M01 00032//PHS HHS; M01 RR00052/RR/NCRR NIH HHS; M01 RR00827/RR/NCRR NIH HHS; M01-RR00080/RR/NCRR NIH HHS; P20-RR11145/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine |
| Comments/Corrections | |
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