Document Detail


Correlates of N-terminal prohormone brain natriuretic peptides in African Americans with hypertensive chronic kidney disease: the African American Study of Kidney Disease and Hypertension.
MedLine Citation:
PMID:  18824845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: The N-amino-terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) is a marker of cardiac stress and elevated levels are indicative of heart failure. Few correlates of NT-proBNP levels have been identified in persons with moderate chronic kidney disease (CKD), and data from those without heart failure and from African Americans are especially limited. METHODS: The African American Study of Kidney Disease and Hypertension (AASK) enrolled nondiabetic African Americans with hypertensive kidney disease (glomerular filtration rate [GFR] = 20-65 ml/min/1.73 m(2)) and no evidence of clinical heart failure. NT-proBNP was measured in 982 AASK participants. RESULTS: In unadjusted analyses, GFR (r = -0.39; p < 0.001), hematocrit (r = -0.21; p < 0.001) and body mass index (BMI; r = -0.07; p = 0.04) were inversely correlated, and systolic blood pressure (r = 0.30; p < 0.001) and log UPCR (r = 0.32; p < 0.001) were positively correlated with log NT-proBNP levels. After adjustment for potential confounders, lower GFR and hematocrit and higher systolic blood pressure and protein:creatinine ratio remained significantly associated with higher NT-proBNP. CONCLUSION: Lower GFR and hematocrit, and higher urinary protein excretion may be associated with volume expansion in CKD. These results suggest that these processes are associated with increased NT-proBNP in CKD and may play a role in the development of heart failure.
Authors:
S Yi; G Contreras; E R Miller; L J Appel; B C Astor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-09-29
Journal Detail:
Title:  American journal of nephrology     Volume:  29     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-05-21     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  292-8     Citation Subset:  IM    
Affiliation:
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Md., USA. ssyi@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans / statistics & numerical data*
Aged
Body Mass Index
Creatinine / urine
Female
Glomerular Filtration Rate
Heart Failure / blood,  ethnology
Hematocrit
Humans
Hypertension, Renal / blood*,  ethnology*
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Proteinuria / blood,  ethnology
Renal Insufficiency, Chronic / blood*,  ethnology*
Risk Factors
Grant Support
ID/Acronym/Agency:
2P20 R11104//PHS HHS; 5M01 RR00071/RR/NCRR NIH HHS; DK2818-02./DK/NIDDK NIH HHS; M01 00032//PHS HHS; M01 RR00052/RR/NCRR NIH HHS; M01 RR00827/RR/NCRR NIH HHS; M01-RR00080/RR/NCRR NIH HHS; P20-RR11145/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine
Comments/Corrections

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