Document Detail

Correlates of MS disability assessed in vivo using aggregates of MR quantities.
MedLine Citation:
PMID:  11376183     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the magnitude of the correlations between disability and composite MRI scores in patients with MS. METHODS: T2- and T1-weighted MRI, magnetization transfer imaging, diffusion tensor imaging, and MRS imaging scans of the brain from 23 patients with MS were obtained. T2 lesion volume, T1 lesion volume, brain magnetization transfer ratio, average brain diffusivity (D), and brain N-acetylaspartate/creatine ratio were measured. RESULTS: The correlations between the Expanded Disability Status Scale (EDSS) score and each of the MR quantities taken in isolation were not significant, with the exception of the correlation between EDSS and the NAA/creatine ratio (r = -0.50; p = 0.01). In contrast, three of the composite MR scores computed using regression models were strongly correlated with the EDSS scores (r range, 0.58 to 0.73; p range, 0.004 to 0.0001). The model that included T2 and T1 lesion volumes and brain D explained 34% of the EDSS variance; the model that included T2 and T1 lesion volumes and brain N-acetylaspartate/creatine ratio explained 36% of the EDSS variance; the model that included T1 lesion volume, brain D, and brain N-acetylaspartate/creatine ratio explained 53% of the EDSS variance. CONCLUSIONS: The results suggest that multiparametric MR models have the potential to provide powerful measures to monitor MS evolution.
C Mainero; N De Stefano; G Iannucci; M P Sormani; L Guidi; A Federico; M L Bartolozzi; G Comi; M Filippi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  56     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-28     Completed Date:  2001-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1331-4     Citation Subset:  AIM; IM    
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Brain / metabolism,  pathology*,  physiopathology*
Creatine / metabolism
Disability Evaluation
Magnetic Resonance Imaging
Middle Aged
Models, Neurological
Multiple Sclerosis / metabolism,  pathology*,  physiopathology*
Predictive Value of Tests
Reg. No./Substance:
56-84-8/Aspartic Acid; 57-00-1/Creatine; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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