Document Detail

Correlates of the FTO gene variant (rs9939609) and growth of American Indian infants.
MedLine Citation:
PMID:  21491999     Owner:  NLM     Status:  MEDLINE    
AIM: Obesity is a global, growing public-health problem. The detrimental health consequences of obesity are significant and include co-morbidities such as diabetes, coronary heart disease, and some types of cancer. To date, findings relating the A allele of the FTO variant rs9939609 to increased energy intake and risk for obesity have been fairly consistent across multiple populations. However, it is not known whether that relationship is also present in American Indian (AI) populations. The purpose of this study was to examine the minor allele frequency of the FTO variant rs9939609 and its associations with birth weight, weight for length (WFL) Z score, and amount of formula intake in AI infants.
DESIGN: A cross-sectional exploratory descriptive design was applied with a sample of 49 AI mother-infant dyads.
RESULTS: Mothers with an A allele had higher prepregnancy body mass index than those without an A allele, though difference was not statistically significant (p=0.08). Infants with an A allele tended to have higher birth weights, WFL Z score at age 14 to 20 weeks, and 24-h formula consumption compared with infants without an A-allele, though those differences were not statistically significant (p>0.05). Neither maternal nor infant A alleles were statistically significantly associated with birth weight, WFL Z score, and amount of formula intake in AI infants (p>0.05).
CONCLUSIONS: The findings do not confirm the association of the A allele of the FTO variant rs9939609 with birth weight, amount of formula intake, and WFL Z score in AI infants.
Nuananong Seal; Michael Weaver; Lyle G Best
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-14
Journal Detail:
Title:  Genetic testing and molecular biomarkers     Volume:  15     ISSN:  1945-0257     ISO Abbreviation:  Genet Test Mol Biomarkers     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2013-03-14     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  101494210     Medline TA:  Genet Test Mol Biomarkers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  633-8     Citation Subset:  IM    
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MeSH Terms
Birth Weight / genetics,  physiology
Body Weight / ethnology,  genetics
Child Development* / physiology
Cross-Sectional Studies
Genetic Association Studies
Genetic Predisposition to Disease / ethnology
Growth and Development / genetics*
Indians, North American / genetics*,  statistics & numerical data
Obesity / epidemiology,  ethnology,  genetics
Pilot Projects
Polymorphism, Single Nucleotide* / physiology
Proteins / genetics*
Young Adult
Grant Support
Reg. No./Substance:
0/FTO protein, human; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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