| Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study. | |
| | |
MedLine Citation:
|
PMID: 20660804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The heart progressively remodels over the life course, yet longitudinal data characterizing such remodeling in the community are limited. METHODS AND RESULTS: Using multilevel modeling, we analyzed up to 4 serial echocardiographic observations obtained over a 16-year period in 4062 Framingham Heart Study participants (mean age 45 years, 54% women; 11 485 person-observations). We related left ventricular (LV) wall thickness, LV systolic and diastolic dimensions, and fractional shortening to age, sex, body mass index, blood pressure (including antihypertensive medication use), smoking, and diabetes mellitus (separate analyses for each echocardiographic measure). With advancing age, LV dimensions decreased, whereas fractional shortening and LV wall thickness increased concomitantly. Male sex, body mass index, and blood pressure indices/hypertension treatment were significantly related to both greater LV dimensions and LV wall thickness. The effect of age on cardiac remodeling was influenced by key covariates (P<0.05 for all interactions): Women and individuals with diabetes mellitus experienced greater age-associated increases in LV wall thickness; presence of diabetes or a higher blood pressure was associated with a lesser decrease in LV diastolic dimensions with increasing age; and antihypertensive medication use was a marker of an attenuated increase in fractional shortening with aging. CONCLUSIONS: Cardiac remodeling over the adult life course is characterized by a distinct pattern of increasing LV wall thickness, decreasing LV dimensions, and increasing fractional shortening with advancing age. Overall, female sex, greater blood pressure load, and presence of diabetes mellitus serve to attenuate this remodeling pattern. These observations suggest a mechanism for the preponderance of women with hypertension and individuals with diabetes among patients with diastolic heart failure. |
| | |
Authors:
|
Susan Cheng; Vanessa Xanthakis; Lisa M Sullivan; Wolfgang Lieb; Joseph Massaro; Jayashri Aragam; Emelia J Benjamin; Ramachandran S Vasan |
Related Documents
:
|
6579824 - Increased cardiac output and lowered peripheral resistance during metoprolol treatment. 1313724 - Myocardial hypertrophy, cardiac beta-adrenoceptors and adenylate cyclase activity durin... 10843104 - Three-dimensional echocardiography: assessment of inter- and intra-operator variability... 11587404 - Impact of dialysis adequacy on cardiac function in pediatric capd patients. 22486634 - Evaluation of vapor intrusion using controlled building pressure. 12914044 - Single-wall carbon nanotubes under high pressures to 62 gpa studied using designer diam... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-26 |
Journal Detail:
|
Title: Circulation Volume: 122 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-10 Completed Date: 2010-08-31 Revised Date: 2011-08-11 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
|
Languages: eng Pagination: 570-8 Citation Subset: AIM; IM |
Affiliation:
|
The Framingham Heart Study, Framingham, MA 01702-5803, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Pressure / physiology Cardiovascular Diseases / epidemiology, physiopathology*, prevention & control Cohort Studies Echocardiography / trends* Female Follow-Up Studies Humans Longevity / physiology* Longitudinal Studies Male Middle Aged Sex Factors Ventricular Remodeling / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
6R01-NS 17950/NS/NINDS NIH HHS; N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01 HL080124-05/HL/NHLBI NIH HHS; R01 NS017950-28/NS/NINDS NIH HHS; R01HL080124/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pathogenesis of sudden unexpected death in a clinical trial of patients with myocardial infarction a...
Next Document: Improving Evidence-Based Care for Heart Failure in Outpatient Cardiology Practices. Primary Results ...