Document Detail

Correlated Poincaré indices for measuring heart rate variability.
MedLine Citation:
PMID:  18274076     Owner:  NLM     Status:  MEDLINE    
Poincaré indices are usually applied to HRV to summarise long data sets collected over 24 hrs. Many applications of HRV are interested in dynamic, short term changes (<1 min). This study uses Poincaré indices published through the 1990's to the present, to determine which of them are correlated over the short term (25 beats). Dynamic changes were observed in 12 subjects pre-operatively receiving fentanyl and midazolam sedation with ECG collected for 5 mins before and 5 mins after fentanyl administration. Poincaré indices with a strong correlation (r>0.85) between the indices for each of the 12 subjects (p<0.001) (particularly with the common measures SDNN, RMSSD, pNN50 and meanRR) were identified. These indices will not be used for further investigation of dynamic effects of fentanyl and midazolam, two sedative drugs used in anaesthesia and intensive care. Indices that proved less suitable for short term analysis (eg. presence of outliers, inability to produce a valid index with smaller number of beats) were also identified. A shortlist of Poincaré indices that do not correlate strongly with commonly used measures may prove interesting in determining dynamic characteristics of the effect of sedative drugs on autonomic nervous system activity.
Anne-Louise Smith; Karen J Reynolds; Harry Owen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine     Volume:  30     ISSN:  0158-9938     ISO Abbreviation:  Australas Phys Eng Sci Med     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-03-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8208130     Medline TA:  Australas Phys Eng Sci Med     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  336-41     Citation Subset:  IM    
Flinders Biomedical Engineering, Flinders Medical Centre, Adelaide, Australia.
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MeSH Terms
Analysis of Variance
Anesthetics, Intravenous / pharmacology
Biophysical Phenomena
Data Interpretation, Statistical
Databases, Factual
Fentanyl / pharmacology
Heart Rate / drug effects,  physiology*
Middle Aged
Reg. No./Substance:
0/Anesthetics, Intravenous; 437-38-7/Fentanyl

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