Document Detail

Correction of uremic cellular injury with a protein-restricted amino acid-supplemented diet.
MedLine Citation:
PMID:  2408467     Owner:  NLM     Status:  MEDLINE    
Untreated patients with uremia show an abnormally low resting transmembrane potential (Em) of skeletal muscle cells. This finding corresponds to impaired sodium transport. Adequate hemodialysis corrects this abnormality. Toxins derived from protein precursors have been implicated as the hypothetical cause of impaired transport and membrane depolarization in untreated uremia. To inferentially examine this hypothesis in further detail, we deliberately reduced dialysis time until Em fell in six uremic patients in whom it had been previously corrected. When Em fell, we examined the effect of reducing crude protein in their diet in conjunction with adding an essential amino acid supplement. Five of six patients who complied with the diet showed correction of their abnormally low Em despite continued reduction of dialysis time. These findings support the notion that in patients with uremia, a product of crude dietary protein may be responsible for membrane depolarization and, in addition, direct measurement of resting muscle transmembrane potential may be a useful index to determine adequacy of dialysis therapy.
J R Cotton; T Woodard; J P Knochel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  5     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-02     Completed Date:  1985-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  IM    
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MeSH Terms
Amino Acids / therapeutic use*
Dietary Proteins / administration & dosage*
Food, Fortified
Ion Channels
Kidney Failure, Chronic / metabolism,  physiopathology
Membrane Potentials
Nitrogen / metabolism
Renal Dialysis
Sodium / metabolism
Time Factors
Uremia / blood,  diet therapy*,  pathology
Reg. No./Substance:
0/Amino Acids; 0/Dietary Proteins; 0/Ion Channels; 7440-23-5/Sodium; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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