Document Detail


Correction of renal hypertension in the rat by prolonged infusion of angiotensin inhibitors.
MedLine Citation:
PMID:  74729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Injection of saralasin or converting-enzyme inhibitor produced a small variable reduction of blood-pressure in rats with two-kidney hypertension. Prolonged infusion of the inhibitors gradually reduced blood-pressure to normal. Control infusions of saralasin in normal animals and of dextrose in normal and hypertensive animals did not reduce blood-pressure. Plasma-renin concentration correlated significantly with the early but not with the later fall of blood-pressure. Plasma-concentrations of renin and angiotensin II were closely related except in rats receiving converting-enzyme inhibitor, when angiotensin II was relatively reduced. The gradual reduction of arterial pressure by saralasin was not associated with increased urinary sodium excretion.
Authors:
A J Riegger; A F Lever; J A Millar; J J Morton; B Slack
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:    1977 Dec 24-31
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1317-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin I / therapeutic use
Angiotensin II / analogs & derivatives*,  blood
Angiotensin-Converting Enzyme Inhibitors*
Animals
Blood Pressure / drug effects
Female
Glucose / administration & dosage,  therapeutic use
Hypertension, Renal / blood,  drug therapy*
Infusions, Parenteral
Rats
Renin / blood
Saralasin / administration & dosage*,  therapeutic use
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 50-99-7/Glucose; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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