Document Detail

Correction of first trimester biochemical aneuploidy screening markers for smoking status: influence of gestational age, maternal ethnicity and cigarette dosage.
MedLine Citation:
PMID:  23169109     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To examine the gestational age, maternal ethnicity and cigarette dosage effects of the reduction of maternal serum pregnancy-associated plasma protein A (PAPP-A) and free-β human chorionic gonadotrophin (free hCGβ) in smokers. METHODS: Maternal serum PAPP-A and free hCGβ corrected for confounders, excluding smoking, in first trimester smokers and nonsmokers were compared by gestational age, maternal ethnicity and cigarette dosage. A small set of second trimester smokers and nonsmoker controls were analysed for PAPP-A along with free hCGβ and assessed for gestational age effects of smoking. RESULTS: Pregnancy-associated plasma protein A reduction by smoking in the first trimester was not influenced by gestational age, however free hCGβ levels were only significantly reduced in weeks 12 and 13 in smokers. Ethnicity and cigarette dosage were also found to influence the reduction of both makers in smokers in the first trimester. In second trimester smokers, PAPP-A was found to be reduced by less and free hCGβ reduced by more than in the first trimester, although no second trimester gestational age effect on smoking was found. CONCLUSIONS: Current methods of correcting for smoking status may be an oversimplification of a more complex subject. © 2012 John Wiley & Sons, Ltd.
Kevin Spencer; Nicholas J Cowans
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-20
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-8     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Prenatal Research Unit, Department of Clinical Biochemistry, King George Hospital, Barley Lane, Goodmayes, IG3 8YB, UK.
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