Document Detail

Correction of essential fatty acid deficiency in newborn infants by cutaneous application of sunflower-seed oil.
MedLine Citation:
PMID:  824609     Owner:  NLM     Status:  MEDLINE    
Two newborn infants receiving long-term, fat-free parenteral nutrition developed essential fatty acid (EFA) deficiency. Biochemical evidence of EFA deficiency was documented in plasma, red blood cells, and adipose tissue and included a decrease in arachidonic and linoleic acids, an increase in 5,8,11-eicosatrienoic acid, palmitoleic and oleic acids and a trienoic/tetraenoic ratio of more than 0.4. Cutaneous application of sunflower-seed oil, a source rich in the essential fat linoleic acid, rapidly reversed the clinical and biochemical manifestations of deficiency in plasma.
Z Friedman; S J Shochat; M J Maisels; K H Marks; E L Lamberth
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  58     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  AIM; IM    
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MeSH Terms
Adipose Tissue / metabolism
Administration, Topical
Dermatitis / drug therapy
Fatty Acids, Essential / blood,  deficiency*
Infant Nutrition Disorders / blood,  complications,  drug therapy*
Infant, Newborn
Infant, Newborn, Diseases / drug therapy*,  therapy
Oils, Volatile / administration & dosage*
Parenteral Nutrition, Total / adverse effects
Phospholipids / blood
Platelet Aggregation / drug effects
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Oils, Volatile; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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